{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11(4)"],"submitter":["van Henten S"],"funding":["Institute of Tropical Medicine","Directorate-General for Development Cooperation and Humanitarian Aid","University of Gondar"],"pubmed_abstract":["<h4>Background</h4>Diagnosis of cutaneous leishmaniasis (CL) usually relies on invasive samples, but it is unclear whether more patient-friendly tools are good alternatives for diverse lesions when used with polymerase chain reaction (PCR).<h4>Methods</h4>Patients with suspected CL were enrolled consecutively in a prospective diagnostic accuracy study. We compared dental broach, tape disc, and microbiopsy samples with PCR as index tests, using PCR with skin slit samples as reference test. Subsequently, we constructed a composite reference test including microscopy, the 3 index tests and skin slit PCR, and we compared these same tests with the composite reference test. We assessed diagnostic accuracy parameters with 95% confidence intervals for all comparisons.<h4>Results</h4>Among 344 incl"],"journal":["Open forum infectious diseases"],"pagination":["ofae113"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10977625"],"repository":["biostudies-literature"],"pubmed_title":["Evaluation of Less Invasive Sampling Tools for the Diagnosis of Cutaneous Leishmaniasis."],"pmcid":["PMC10977625"],"pubmed_authors":["Engidaw A","Vogt F","Mekonnen T","Moons KGM","Mulaw T","Melkamu R","Dessie D","van Henten S","Pareyn M","van Griensven J","Cnops L","Fikre H","Bogale T","Yeshanew A","Kassa M"],"additional_accession":[]},"is_claimable":false,"name":"Evaluation of Less Invasive Sampling Tools for the Diagnosis of Cutaneous Leishmaniasis.","description":"<h4>Background</h4>Diagnosis of cutaneous leishmaniasis (CL) usually relies on invasive samples, but it is unclear whether more patient-friendly tools are good alternatives for diverse lesions when used with polymerase chain reaction (PCR).<h4>Methods</h4>Patients with suspected CL were enrolled consecutively in a prospective diagnostic accuracy study. We compared dental broach, tape disc, and microbiopsy samples with PCR as index tests, using PCR with skin slit samples as reference test. Subsequently, we constructed a composite reference test including microscopy, the 3 index tests and skin slit PCR, and we compared these same tests with the composite reference test. We assessed diagnostic accuracy parameters with 95% confidence intervals for all comparisons.<h4>Results</h4>Among 344 incl","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Apr","modification":"2026-04-08T15:17:55.976Z","creation":"2025-04-06T07:44:49.852Z"},"accession":"S-EPMC10977625","cross_references":{"pubmed":["38560600"],"doi":["10.1093/ofid/ofae113"]}}