{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sengupta T"],"funding":["Centers for Disease Control and Prevention","Office of the Director","NCCIH NIH HHS","NIA NIH HHS","Damon Runyon Cancer Research Foundation","NIGMS NIH HHS","National Science Foundation","NIGMS","Ford Foundation"],"pagination":["e1011178"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10977744"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(3)"],"pubmed_abstract":["C. elegans can learn to avoid pathogenic bacteria through several mechanisms, including bacterial small RNA-induced learned avoidance behavior, which can be inherited transgenerationally. Previously, we discovered that a small RNA from a clinical isolate of Pseudomonas aeruginosa, PA14, induces learned avoidance and transgenerational inheritance of that avoidance in C. elegans. Pseudomonas aeruginosa is an important human pathogen, and there are other Pseudomonads in C. elegans' natural habitat, but it is unclear whether C. elegans ever encounters PA14-like bacteria in the wild. Thus, it is not known if small RNAs from bacteria found in C. elegans' natural habitat can also regulate host behavior and produce heritable behavioral effects. Here we screened a set of wild habitat bacteria, and "],"journal":["PLoS genetics"],"pubmed_title":["A natural bacterial pathogen of C. elegans uses a small RNA to induce transgenerational inheritance of learned avoidance."],"pmcid":["PMC10977744"],"funding_grant_id":["DGE-2039656","T32 GM007388","DP1 AG077430","T32GM007388","DP1 GM119167","1R01AT011963-01","R01 AT011963","DRG-2481-22","75D30122C15113","DP1GM119167"],"pubmed_authors":["Myhrvold C","Kaletsky R","Gitai Z","Marogi J","Moore RS","Sengupta T","St Ange J","Seto RJ","Murphy CT"],"additional_accession":[]},"is_claimable":false,"name":"A natural bacterial pathogen of C. elegans uses a small RNA to induce transgenerational inheritance of learned avoidance.","description":"C. elegans can learn to avoid pathogenic bacteria through several mechanisms, including bacterial small RNA-induced learned avoidance behavior, which can be inherited transgenerationally. Previously, we discovered that a small RNA from a clinical isolate of Pseudomonas aeruginosa, PA14, induces learned avoidance and transgenerational inheritance of that avoidance in C. elegans. Pseudomonas aeruginosa is an important human pathogen, and there are other Pseudomonads in C. elegans' natural habitat, but it is unclear whether C. elegans ever encounters PA14-like bacteria in the wild. Thus, it is not known if small RNAs from bacteria found in C. elegans' natural habitat can also regulate host behavior and produce heritable behavioral effects. Here we screened a set of wild habitat bacteria, and ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2026-07-16T12:04:40.337Z","creation":"2025-04-19T10:15:25.584Z"},"accession":"S-EPMC10977744","cross_references":{"pubmed":["38547071"],"doi":["10.1371/journal.pgen.1011178"]}}