{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lee R"],"funding":["National Institute of Environmental Health Sciences","NIEHS NIH HHS","National Heart, Lung, and Blood Institute","NHLBI NIH HHS"],"pagination":["204-215"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10978238"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["38(3)"],"pubmed_abstract":["<h4>Background</h4>Reported rates of maternal mortality in the United States have been staggeringly high and increasing, and cardiovascular disease (CVD) is a chief contributor to such deaths. However, the impact of hypertensive disorders of pregnancy (HDP) on the short-term risk of cardiovascular death is not well understood.<h4>Objectives</h4>To evaluate the association between HDP (chronic hypertension, gestational hypertension, preeclampsia, eclampsia, and superimposed preeclampsia) and pregnancy-associated mortality rates (PMR) from all causes, CVD-related causes both at delivery and within 1 year following delivery.<h4>Methods</h4>We used the Nationwide Readmissions Database (2010-2018) to examine PMRs for females 15-54 years old. International Classification of Disease 9 and 10 diagnosis codes were used to identify pregnancy-associated deaths due to HDP and CVD. Discrete-time Cox proportional hazards regression models were used to calculate adjusted hazard ratios (HR) and 95% confidence intervals (CI) for mortality at delivery (0 days) and at <30, <60, <90, <180, and <365 days after delivery in relation to HDP.<h4>Results</h4>Of 33,417,736 hospital deliveries, the rate of HDP was 11.0% (n = 3,688,967), and the PMR from CVD was 6.4 per 100,000 delivery hospitalisations (n = 2141). Compared with normotensive patients, HRs for CVD-related PMRs increased with HDP severity, reaching over 58-fold for eclampsia patients. HRs were higher for stroke-related (1.2 to 170.9) than heart disease (HD)-related (0.99 to 39.8) mortality across all HDPs. Except for gestational hypertension, the increased risks of CVD mortality were evident at delivery and persisted 1 year postpartum for all HDPs.<h4>Conclusions</h4>HDPs are strong risk factors for pregnancy-associated mortality due to CVD at delivery and within 1 year postpartum; the risks are stronger for stroke than HD-related PMR. While absolute PMRs are low, this study supports the importance of extending postpartum care beyond the traditional 42-day postpartum visit for people whose pregnancies are complicated by hypertension."],"journal":["Paediatric and perinatal epidemiology"],"pubmed_title":["Pregnancy-associated mortality due to cardiovascular disease: Impact of hypertensive disorders of pregnancy."],"pmcid":["PMC10978238"],"funding_grant_id":["R01‐ES033190","R01-ES033190","R01 HL150065","R01 ES033190","R01-HL150065","R01‐HL150065"],"pubmed_authors":["Lee R","Ananth CV","Joseph KS","Brandt JS"],"additional_accession":[]},"is_claimable":false,"name":"Pregnancy-associated mortality due to cardiovascular disease: Impact of hypertensive disorders of pregnancy.","description":"<h4>Background</h4>Reported rates of maternal mortality in the United States have been staggeringly high and increasing, and cardiovascular disease (CVD) is a chief contributor to such deaths. However, the impact of hypertensive disorders of pregnancy (HDP) on the short-term risk of cardiovascular death is not well understood.<h4>Objectives</h4>To evaluate the association between HDP (chronic hypertension, gestational hypertension, preeclampsia, eclampsia, and superimposed preeclampsia) and pregnancy-associated mortality rates (PMR) from all causes, CVD-related causes both at delivery and within 1 year following delivery.<h4>Methods</h4>We used the Nationwide Readmissions Database (2010-2018) to examine PMRs for females 15-54 years old. International Classification of Disease 9 and 10 diagnosis codes were used to identify pregnancy-associated deaths due to HDP and CVD. Discrete-time Cox proportional hazards regression models were used to calculate adjusted hazard ratios (HR) and 95% confidence intervals (CI) for mortality at delivery (0 days) and at <30, <60, <90, <180, and <365 days after delivery in relation to HDP.<h4>Results</h4>Of 33,417,736 hospital deliveries, the rate of HDP was 11.0% (n = 3,688,967), and the PMR from CVD was 6.4 per 100,000 delivery hospitalisations (n = 2141). Compared with normotensive patients, HRs for CVD-related PMRs increased with HDP severity, reaching over 58-fold for eclampsia patients. HRs were higher for stroke-related (1.2 to 170.9) than heart disease (HD)-related (0.99 to 39.8) mortality across all HDPs. Except for gestational hypertension, the increased risks of CVD mortality were evident at delivery and persisted 1 year postpartum for all HDPs.<h4>Conclusions</h4>HDPs are strong risk factors for pregnancy-associated mortality due to CVD at delivery and within 1 year postpartum; the risks are stronger for stroke than HD-related PMR. While absolute PMRs are low, this study supports the importance of extending postpartum care beyond the traditional 42-day postpartum visit for people whose pregnancies are complicated by hypertension.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2025-04-03T23:34:02.797Z","creation":"2025-04-03T23:34:02.797Z"},"accession":"S-EPMC10978238","cross_references":{"pubmed":["38375930"],"doi":["10.1111/ppe.13055"]}}