{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kamogawa N"],"funding":["NIBIB NIH HHS","NINDS NIH HHS"],"pagination":["895-904"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10978262"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["55(4)"],"pubmed_abstract":["Background
Stroke with unknown time of onset can be categorized into 2 groups; wake-up stroke (WUS) and unwitnessed stroke with an onset time unavailable for reasons other than wake-up (non-wake-up unwitnessed stroke, non-WUS). We aimed to assess potential differences in the efficacy and safety of intravenous thrombolysis (IVT) between these subgroups.Methods
Patients with an unknown-onset stroke were evaluated using individual patient-level data of 2 randomized controlled trials (WAKE-UP [Efficacy and Safety of MRI-Based Thrombolysis in Wake-Up Stroke], THAWS [Thrombolysis for Acute Wake-Up and Unclear-Onset Strokes With Alteplase at 0.6 mg/kg]) comparing IVT with placebo or standard treatment from the EOS (Evaluation of Unknown-Onset Stroke Thrombolysis trial) data set. A"],"journal":["Stroke"],"pubmed_title":["Thrombolysis for Wake-Up Stroke Versus Non-Wake-Up Unwitnessed Stroke: EOS Individual Patient Data Meta-Analysis."],"pmcid":["PMC10978262"],"funding_grant_id":["P41 EB015896","P50 NS051343"],"pubmed_authors":["Bendszus M","Molina C","Thomalla G","Latour L","Wu O","Schwamm LH","Parsons M","Wahlgren N","Evaluation of Unknown Onset Stroke Thrombolysis Trials (EOS) Investigators","Endres M","Hsu CY","Kitazono T","Koga M","Hacke W","Churilov L","Nighoghossian N","Jensen M","Davis SM","Fukuda-Doi M","Yassi N","Miwa K","Donnan GA","Levi C","Fiebach JB","Muir K","Toni D","Kamogawa N","Boutitie F","Warach S","Toyoda K","Simonsen CZ","Cheng B","Song SS","Thijs V","Inoue M","Yoshimura S","Leys D","Schwab S","Ringleb P","Lemmens R","Schellinger PD","Bladin C","Gerloff C","Kleinig T","Ma H","Pedraza S","Campbell B","Ebinger M"],"additional_accession":[]},"is_claimable":false,"name":"Thrombolysis for Wake-Up Stroke Versus Non-Wake-Up Unwitnessed Stroke: EOS Individual Patient Data Meta-Analysis.","description":"Background
Stroke with unknown time of onset can be categorized into 2 groups; wake-up stroke (WUS) and unwitnessed stroke with an onset time unavailable for reasons other than wake-up (non-wake-up unwitnessed stroke, non-WUS). We aimed to assess potential differences in the efficacy and safety of intravenous thrombolysis (IVT) between these subgroups.Methods
Patients with an unknown-onset stroke were evaluated using individual patient-level data of 2 randomized controlled trials (WAKE-UP [Efficacy and Safety of MRI-Based Thrombolysis in Wake-Up Stroke], THAWS [Thrombolysis for Acute Wake-Up and Unclear-Onset Strokes With Alteplase at 0.6 mg/kg]) comparing IVT with placebo or standard treatment from the EOS (Evaluation of Unknown-Onset Stroke Thrombolysis trial) data set. A","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Apr","modification":"2026-06-01T19:09:39.778Z","creation":"2026-05-19T03:07:07.125Z"},"accession":"S-EPMC10978262","cross_references":{"pubmed":["38456303"],"doi":["10.1161/strokeaha.123.043358","10.1161/STROKEAHA.123.043358"]}}