biostudies-literatureKamogawa NNIBIB NIH HHSNINDS NIH HHS895-904https://www.ebi.ac.uk/biostudies/studies/S-EPMC10978262biostudies-literatureUnknown55(4)<h4>Background</h4>Stroke with unknown time of onset can be categorized into 2 groups; wake-up stroke (WUS) and unwitnessed stroke with an onset time unavailable for reasons other than wake-up (non-wake-up unwitnessed stroke, non-WUS). We aimed to assess potential differences in the efficacy and safety of intravenous thrombolysis (IVT) between these subgroups.<h4>Methods</h4>Patients with an unknown-onset stroke were evaluated using individual patient-level data of 2 randomized controlled trials (WAKE-UP [Efficacy and Safety of MRI-Based Thrombolysis in Wake-Up Stroke], THAWS [Thrombolysis for Acute Wake-Up and Unclear-Onset Strokes With Alteplase at 0.6 mg/kg]) comparing IVT with placebo or standard treatment from the EOS (Evaluation of Unknown-Onset Stroke Thrombolysis trial) data set. AStrokeThrombolysis for Wake-Up Stroke Versus Non-Wake-Up Unwitnessed Stroke: EOS Individual Patient Data Meta-Analysis.PMC10978262P41 EB015896P50 NS051343Bendszus MMolina CThomalla GLatour LWu OSchwamm LHParsons MWahlgren NEvaluation of Unknown Onset Stroke Thrombolysis Trials (EOS) InvestigatorsEndres MHsu CYKitazono TKoga MHacke WChurilov LNighoghossian NJensen MDavis SMFukuda-Doi MYassi NMiwa KDonnan GALevi CFiebach JBMuir KToni DKamogawa NBoutitie FWarach SToyoda KSimonsen CZCheng BSong SSThijs VInoue MYoshimura SLeys DSchwab SRingleb PLemmens RSchellinger PDBladin CGerloff CKleinig TMa HPedraza SCampbell BEbinger MfalseThrombolysis for Wake-Up Stroke Versus Non-Wake-Up Unwitnessed Stroke: EOS Individual Patient Data Meta-Analysis.<h4>Background</h4>Stroke with unknown time of onset can be categorized into 2 groups; wake-up stroke (WUS) and unwitnessed stroke with an onset time unavailable for reasons other than wake-up (non-wake-up unwitnessed stroke, non-WUS). We aimed to assess potential differences in the efficacy and safety of intravenous thrombolysis (IVT) between these subgroups.<h4>Methods</h4>Patients with an unknown-onset stroke were evaluated using individual patient-level data of 2 randomized controlled trials (WAKE-UP [Efficacy and Safety of MRI-Based Thrombolysis in Wake-Up Stroke], THAWS [Thrombolysis for Acute Wake-Up and Unclear-Onset Strokes With Alteplase at 0.6 mg/kg]) comparing IVT with placebo or standard treatment from the EOS (Evaluation of Unknown-Onset Stroke Thrombolysis trial) data set. A2024-01-01T00:00:00Z2024 Apr2026-06-01T19:09:39.778Z2026-05-19T03:07:07.125ZS-EPMC109782623845630310.1161/strokeaha.123.04335810.1161/STROKEAHA.123.043358