{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Nitkowski J"],"funding":["NCATS NIH HHS","NCI NIH HHS"],"pagination":["270-275"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10978280"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["51(4)"],"pubmed_abstract":["<h4>Background</h4>Home-based self-sampling may be a viable option for anal cancer screening among sexual minority men (SMM). Yet limited research has compared home-based self-collected with clinician-collected anal swabs for human papillomavirus (HPV) genotyping.<h4>Methods</h4>The Prevent Anal Cancer Self-Swab Study recruited SMM and transgender persons 25 years and over in Milwaukee, WI to participate in an anal cancer screening study. Participants were randomized to a home or clinic arm. Home-based participants were mailed an anal self-sampling kit to complete and return via postal mail. They were also asked to attend a clinic appointment where a clinician collected an anal swab. Swabs were HPV-genotyped using the SPF 10 -LiPA 25 assay. We analyzed 79 paired self and clinician swabs to determine HPV prevalence, percent agreement, and sensitivity and specificity of the mailed home-based anal self-swab to detect HPV genotypes using the clinician-collected swab as the reference.<h4>Results</h4>The median number of days between the home and clinic swab was 19 days (range = 2 to 70). Human papillomavirus was detected in 73.3% of self and 75.0% of clinician anal swabs ( P = 0.99). Prevalence of any HPV, any high-risk HPV, any low-risk HPV, and individual HPV types did not significantly differ between self and clinician anal swabs. Agreement between self and clinician swabs was over 90% for 21 of the 25 HPV genotypes. Mailed home-based self-collected swabs had a sensitivity of 94.1% (95% confidence interval, 82.9-99.0) for detection of high-risk HPV versus clinician-collected sampling.<h4>Conclusions</h4>Mailed home-based self-collected and clinician-collected anal swabs demonstrated high concordance for HPV genotyping."],"journal":["Sexually transmitted diseases"],"pubmed_title":["Concordance of Human Papillomavirus Genotypes in Mailed Home-Based Self-Collected Versus Clinician-Collected Anal Swabs Among Sexual and Gender Minority Individuals."],"pmcid":["PMC10978280"],"funding_grant_id":["UL1 TR001436","R01 CA215403"],"pubmed_authors":["Ridolfi T","Fernandez ME","Giuliano AR","Schick V","Swartz MD","Nitkowski J","Chiao E","Nyitray AG","Smith JS"],"additional_accession":[]},"is_claimable":false,"name":"Concordance of Human Papillomavirus Genotypes in Mailed Home-Based Self-Collected Versus Clinician-Collected Anal Swabs Among Sexual and Gender Minority Individuals.","description":"<h4>Background</h4>Home-based self-sampling may be a viable option for anal cancer screening among sexual minority men (SMM). Yet limited research has compared home-based self-collected with clinician-collected anal swabs for human papillomavirus (HPV) genotyping.<h4>Methods</h4>The Prevent Anal Cancer Self-Swab Study recruited SMM and transgender persons 25 years and over in Milwaukee, WI to participate in an anal cancer screening study. Participants were randomized to a home or clinic arm. Home-based participants were mailed an anal self-sampling kit to complete and return via postal mail. They were also asked to attend a clinic appointment where a clinician collected an anal swab. Swabs were HPV-genotyped using the SPF 10 -LiPA 25 assay. We analyzed 79 paired self and clinician swabs to determine HPV prevalence, percent agreement, and sensitivity and specificity of the mailed home-based anal self-swab to detect HPV genotypes using the clinician-collected swab as the reference.<h4>Results</h4>The median number of days between the home and clinic swab was 19 days (range = 2 to 70). Human papillomavirus was detected in 73.3% of self and 75.0% of clinician anal swabs ( P = 0.99). Prevalence of any HPV, any high-risk HPV, any low-risk HPV, and individual HPV types did not significantly differ between self and clinician anal swabs. Agreement between self and clinician swabs was over 90% for 21 of the 25 HPV genotypes. Mailed home-based self-collected swabs had a sensitivity of 94.1% (95% confidence interval, 82.9-99.0) for detection of high-risk HPV versus clinician-collected sampling.<h4>Conclusions</h4>Mailed home-based self-collected and clinician-collected anal swabs demonstrated high concordance for HPV genotyping.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Apr","modification":"2025-07-10T03:08:24.766Z","creation":"2025-07-10T03:08:24.766Z"},"accession":"S-EPMC10978280","cross_references":{"pubmed":["38133570"],"doi":["10.1097/OLQ.0000000000001916","10.1097/olq.0000000000001916"]}}