{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Mesquita T"],"funding":["NIAID NIH HHS","NHLBI NIH HHS"],"pagination":["e117-e130"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10978283"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["44(4)"],"pubmed_abstract":["<h4>Background</h4>Kawasaki disease (KD) is an acute febrile illness and systemic vasculitis often associated with cardiac sequelae, including arrhythmias. Abundant evidence indicates a central role for IL (interleukin)-1 and TNFα (tumor necrosis factor-alpha) signaling in the formation of arterial lesions in KD. We aimed to investigate the mechanisms underlying the development of electrophysiological abnormalities in a murine model of KD vasculitis.<h4>Methods</h4><i>Lactobacillus casei</i> cell wall extract-induced KD vasculitis model was used to investigate the therapeutic efficacy of clinically relevant IL-1Ra (IL-1 receptor antagonist) and TNFα neutralization. Echocardiography, in vivo electrophysiology, whole-heart optical mapping, and imaging were performed.<h4>Results</h4>KD vascul"],"journal":["Arteriosclerosis, thrombosis, and vascular biology"],"pubmed_title":["Inhibition of IL-1 Ameliorates Cardiac Dysfunction and Arrhythmias in a Murine Model of Kawasaki Disease."],"pmcid":["PMC10978283"],"funding_grant_id":["R01 AI072726","R01 HL159297","R01 AI157274","R01 HL147570","R01 HL135866"],"pubmed_authors":["Fishbein MC","Miguel-Dos-Santos R","Cingolani E","Noval Rivas M","Atici AE","Mesquita T","Lee Y","Chen S","Arditi M","Lin YN"],"additional_accession":[]},"is_claimable":false,"name":"Inhibition of IL-1 Ameliorates Cardiac Dysfunction and Arrhythmias in a Murine Model of Kawasaki Disease.","description":"<h4>Background</h4>Kawasaki disease (KD) is an acute febrile illness and systemic vasculitis often associated with cardiac sequelae, including arrhythmias. Abundant evidence indicates a central role for IL (interleukin)-1 and TNFα (tumor necrosis factor-alpha) signaling in the formation of arterial lesions in KD. We aimed to investigate the mechanisms underlying the development of electrophysiological abnormalities in a murine model of KD vasculitis.<h4>Methods</h4><i>Lactobacillus casei</i> cell wall extract-induced KD vasculitis model was used to investigate the therapeutic efficacy of clinically relevant IL-1Ra (IL-1 receptor antagonist) and TNFα neutralization. Echocardiography, in vivo electrophysiology, whole-heart optical mapping, and imaging were performed.<h4>Results</h4>KD vascul","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Apr","modification":"2025-07-02T03:04:41.219Z","creation":"2025-07-02T03:04:41.219Z"},"accession":"S-EPMC10978283","cross_references":{"pubmed":["38385289"],"doi":["10.1161/ATVBAHA.123.320382","10.1161/atvbaha.123.320382"]}}