biostudies-literatureMesquita TNIAID NIH HHSNHLBI NIH HHSe117-e130https://www.ebi.ac.uk/biostudies/studies/S-EPMC10978283biostudies-literatureUnknown44(4)<h4>Background</h4>Kawasaki disease (KD) is an acute febrile illness and systemic vasculitis often associated with cardiac sequelae, including arrhythmias. Abundant evidence indicates a central role for IL (interleukin)-1 and TNFα (tumor necrosis factor-alpha) signaling in the formation of arterial lesions in KD. We aimed to investigate the mechanisms underlying the development of electrophysiological abnormalities in a murine model of KD vasculitis.<h4>Methods</h4><i>Lactobacillus casei</i> cell wall extract-induced KD vasculitis model was used to investigate the therapeutic efficacy of clinically relevant IL-1Ra (IL-1 receptor antagonist) and TNFα neutralization. Echocardiography, in vivo electrophysiology, whole-heart optical mapping, and imaging were performed.<h4>Results</h4>KD vasculArteriosclerosis, thrombosis, and vascular biologyInhibition of IL-1 Ameliorates Cardiac Dysfunction and Arrhythmias in a Murine Model of Kawasaki Disease.PMC10978283R01 AI072726R01 HL159297R01 AI157274R01 HL147570R01 HL135866Fishbein MCMiguel-Dos-Santos RCingolani ENoval Rivas MAtici AEMesquita TLee YChen SArditi MLin YNfalseInhibition of IL-1 Ameliorates Cardiac Dysfunction and Arrhythmias in a Murine Model of Kawasaki Disease.<h4>Background</h4>Kawasaki disease (KD) is an acute febrile illness and systemic vasculitis often associated with cardiac sequelae, including arrhythmias. Abundant evidence indicates a central role for IL (interleukin)-1 and TNFα (tumor necrosis factor-alpha) signaling in the formation of arterial lesions in KD. We aimed to investigate the mechanisms underlying the development of electrophysiological abnormalities in a murine model of KD vasculitis.<h4>Methods</h4><i>Lactobacillus casei</i> cell wall extract-induced KD vasculitis model was used to investigate the therapeutic efficacy of clinically relevant IL-1Ra (IL-1 receptor antagonist) and TNFα neutralization. Echocardiography, in vivo electrophysiology, whole-heart optical mapping, and imaging were performed.<h4>Results</h4>KD vascul2024-01-01T00:00:00Z2024 Apr2025-07-02T03:04:41.219Z2025-07-02T03:04:41.219ZS-EPMC109782833838528910.1161/ATVBAHA.123.32038210.1161/atvbaha.123.320382