{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Love SM"],"funding":["U.S. Department of Health and Human Services","NIA NIH HHS","NHLBI NIH HHS","National Heart, Lung, and Blood Institute","National Institutes of Health"],"pagination":["197-207"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10978295"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["34(2)"],"pubmed_abstract":["<h4>Background</h4>Clonal hematopoiesis of indeterminate potential (CHIP), the expansion of leukemogenic mutations in white blood cells, has been associated with increased risk of atherosclerotic cardiovascular diseases, cancer, and mortality.<h4>Objective</h4>We examined the relationship between individual- and neighborhood-level socioeconomic status (SES) and CHIP and evaluated effect modification by interpersonal and intrapersonal resources.<h4>Methods</h4>The study population included 10,799 postmenopausal women from the Women's Health Initiative without hematologic malignancy or antineoplastic medication use. Individual- and neighborhood (Census tract)-level SES were assessed across several domains including education, income, and occupation, and a neighborhood-level SES summary z-score, which captures multiple dimensions of SES, was generated. Interpersonal and intrapersonal resources were self-reports. CHIP was ascertained based on a prespecified list of leukemogenic driver mutations. Weighted logistic regression models adjusted for covariates were used to estimate risk of CHIP as an odds ratio (OR) and 95% confidence interval (95% CI).<h4>Results</h4>The interval-scale neighborhood-level SES summary z-score was associated with a 3% increased risk of CHIP: OR (95% CI) = 1.03 (1.00-1.05), p = .038. Optimism significantly modified that estimate, such that among women with low/medium and high levels of optimism, the corresponding ORs (95% CIs) were 1.03 (1.02-1.04) and 0.95 (0.94-0.96), p<sub>Interaction</sub> < .001.<h4>Conclusions</h4>Our findings suggest that reduced risk of somatic mutation may represent a biological pathway by which optimism protects contextually advantaged but at-risk women against age-related chronic disease and highlight potential benefits of long-term, positive psychological interventions."],"journal":["Women's health issues : official publication of the Jacobs Institute of Women's Health"],"pubmed_title":["Individual and Neighborhood-level Socioeconomic Status and Somatic Mutations Associated With Increased Risk of Cardiovascular Disease and Mortality: A Cross-Sectional Analysis in the Women's Health Initiative."],"pmcid":["PMC10978295"],"funding_grant_id":["R01 HL151152","T32HL129982","R01HL151152–02W1","R00 AG075327","R01 HL148565","HHSN268201600002C","HHSN268201600003C","T32 HL129982","HHSN268201600001C","HHSN268201600018C","HHSN268201600004C","T32 HL007055"],"pubmed_authors":["Manson JE","Barac A","Anthony KM","Buchheit SF","Bhattacharya R","Reiner A","Desai PM","Bey GS","Whitsel EA","Jaiswal S","Collins JM","Zannas AS","Gondalia R","Kooperberg C","Love SM","Stewart JD","Bick AG","Hayden KM","Butler EN","Natarajan P"],"additional_accession":[]},"is_claimable":false,"name":"Individual and Neighborhood-level Socioeconomic Status and Somatic Mutations Associated With Increased Risk of Cardiovascular Disease and Mortality: A Cross-Sectional Analysis in the Women's Health Initiative.","description":"<h4>Background</h4>Clonal hematopoiesis of indeterminate potential (CHIP), the expansion of leukemogenic mutations in white blood cells, has been associated with increased risk of atherosclerotic cardiovascular diseases, cancer, and mortality.<h4>Objective</h4>We examined the relationship between individual- and neighborhood-level socioeconomic status (SES) and CHIP and evaluated effect modification by interpersonal and intrapersonal resources.<h4>Methods</h4>The study population included 10,799 postmenopausal women from the Women's Health Initiative without hematologic malignancy or antineoplastic medication use. Individual- and neighborhood (Census tract)-level SES were assessed across several domains including education, income, and occupation, and a neighborhood-level SES summary z-score, which captures multiple dimensions of SES, was generated. Interpersonal and intrapersonal resources were self-reports. CHIP was ascertained based on a prespecified list of leukemogenic driver mutations. Weighted logistic regression models adjusted for covariates were used to estimate risk of CHIP as an odds ratio (OR) and 95% confidence interval (95% CI).<h4>Results</h4>The interval-scale neighborhood-level SES summary z-score was associated with a 3% increased risk of CHIP: OR (95% CI) = 1.03 (1.00-1.05), p = .038. Optimism significantly modified that estimate, such that among women with low/medium and high levels of optimism, the corresponding ORs (95% CIs) were 1.03 (1.02-1.04) and 0.95 (0.94-0.96), p<sub>Interaction</sub> < .001.<h4>Conclusions</h4>Our findings suggest that reduced risk of somatic mutation may represent a biological pathway by which optimism protects contextually advantaged but at-risk women against age-related chronic disease and highlight potential benefits of long-term, positive psychological interventions.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar-Apr","modification":"2025-04-03T23:43:04.654Z","creation":"2025-04-03T23:43:04.654Z"},"accession":"S-EPMC10978295","cross_references":{"pubmed":["38061917"],"doi":["10.1016/j.whi.2023.10.005"]}}