biostudies-literatureLove SMU.S. Department of Health and Human ServicesNIA NIH HHSNHLBI NIH HHSNational Heart, Lung, and Blood InstituteNational Institutes of Health197-207https://www.ebi.ac.uk/biostudies/studies/S-EPMC10978295biostudies-literatureUnknown34(2)<h4>Background</h4>Clonal hematopoiesis of indeterminate potential (CHIP), the expansion of leukemogenic mutations in white blood cells, has been associated with increased risk of atherosclerotic cardiovascular diseases, cancer, and mortality.<h4>Objective</h4>We examined the relationship between individual- and neighborhood-level socioeconomic status (SES) and CHIP and evaluated effect modification by interpersonal and intrapersonal resources.<h4>Methods</h4>The study population included 10,799 postmenopausal women from the Women's Health Initiative without hematologic malignancy or antineoplastic medication use. Individual- and neighborhood (Census tract)-level SES were assessed across several domains including education, income, and occupation, and a neighborhood-level SES summary z-score, which captures multiple dimensions of SES, was generated. Interpersonal and intrapersonal resources were self-reports. CHIP was ascertained based on a prespecified list of leukemogenic driver mutations. Weighted logistic regression models adjusted for covariates were used to estimate risk of CHIP as an odds ratio (OR) and 95% confidence interval (95% CI).<h4>Results</h4>The interval-scale neighborhood-level SES summary z-score was associated with a 3% increased risk of CHIP: OR (95% CI) = 1.03 (1.00-1.05), p = .038. Optimism significantly modified that estimate, such that among women with low/medium and high levels of optimism, the corresponding ORs (95% CIs) were 1.03 (1.02-1.04) and 0.95 (0.94-0.96), p_Interaction < .001.<h4>Conclusions</h4>Our findings suggest that reduced risk of somatic mutation may represent a biological pathway by which optimism protects contextually advantaged but at-risk women against age-related chronic disease and highlight potential benefits of long-term, positive psychological interventions.Women's health issues : official publication of the Jacobs Institute of Women's HealthIndividual and Neighborhood-level Socioeconomic Status and Somatic Mutations Associated With Increased Risk of Cardiovascular Disease and Mortality: A Cross-Sectional Analysis in the Women's Health Initiative.PMC10978295R01 HL151152T32HL129982R01HL151152–02W1R00 AG075327R01 HL148565HHSN268201600002CHHSN268201600003CT32 HL129982HHSN268201600001CHHSN268201600018CHHSN268201600004CT32 HL007055Manson JEBarac AAnthony KMBuchheit SFBhattacharya RReiner ADesai PMBey GSWhitsel EAJaiswal SCollins JMZannas ASGondalia RKooperberg CLove SMStewart JDBick AGHayden KMButler ENNatarajan PfalseIndividual and Neighborhood-level Socioeconomic Status and Somatic Mutations Associated With Increased Risk of Cardiovascular Disease and Mortality: A Cross-Sectional Analysis in the Women's Health Initiative.<h4>Background</h4>Clonal hematopoiesis of indeterminate potential (CHIP), the expansion of leukemogenic mutations in white blood cells, has been associated with increased risk of atherosclerotic cardiovascular diseases, cancer, and mortality.<h4>Objective</h4>We examined the relationship between individual- and neighborhood-level socioeconomic status (SES) and CHIP and evaluated effect modification by interpersonal and intrapersonal resources.<h4>Methods</h4>The study population included 10,799 postmenopausal women from the Women's Health Initiative without hematologic malignancy or antineoplastic medication use. Individual- and neighborhood (Census tract)-level SES were assessed across several domains including education, income, and occupation, and a neighborhood-level SES summary z-score, which captures multiple dimensions of SES, was generated. Interpersonal and intrapersonal resources were self-reports. CHIP was ascertained based on a prespecified list of leukemogenic driver mutations. Weighted logistic regression models adjusted for covariates were used to estimate risk of CHIP as an odds ratio (OR) and 95% confidence interval (95% CI).<h4>Results</h4>The interval-scale neighborhood-level SES summary z-score was associated with a 3% increased risk of CHIP: OR (95% CI) = 1.03 (1.00-1.05), p = .038. Optimism significantly modified that estimate, such that among women with low/medium and high levels of optimism, the corresponding ORs (95% CIs) were 1.03 (1.02-1.04) and 0.95 (0.94-0.96), p_Interaction < .001.<h4>Conclusions</h4>Our findings suggest that reduced risk of somatic mutation may represent a biological pathway by which optimism protects contextually advantaged but at-risk women against age-related chronic disease and highlight potential benefits of long-term, positive psychological interventions.2024-01-01T00:00:00Z2024 Mar-Apr2025-04-03T23:43:04.654Z2025-04-03T23:43:04.654ZS-EPMC109782953806191710.1016/j.whi.2023.10.005