{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(3)"],"submitter":["Duivenvoorden WCM"],"pubmed_abstract":["Low testosterone (T), common in aging men, associates with cardiovascular disease. We investigated whether follicle-stimulating hormone (FSH), which is affected by T, modulates the cardiovascular effects associated with low T or castration. FSHβ<sup>-/-</sup>:low-density lipoprotein receptor (LDLR)<sup>-/-</sup> mice, untreated or castrated (orchiectomy, gonadotropin-releasing hormone agonist or antagonist), demonstrated significantly less atherogenesis compared with similarly treated LDLR<sup>-/-</sup> mice, but not following FSH delivery. Smaller plaque burden in LDLR<sup>-/-</sup> mice receiving gonadotropin-releasing hormone antagonists vs agonists were nullified in FSHβ<sup>-/-</sup>:LDLR<sup>-/-</sup> mice. Atherosclerotic and necrotic plaque size and macrophage infiltration correlated with serum FSH/T. In patients with prostate cancer, FSH/T following androgen-deprivation therapy initiation predicted cardiovascular events. FSH facilitates cardiovascular disease when T is low or eliminated."],"journal":["JACC. Basic to translational science"],"pagination":["364-379"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10978407"],"repository":["biostudies-literature"],"pubmed_title":["Follicle-Stimulating Hormone Exacerbates Cardiovascular Disease in the Presence of Low or Castrate Testosterone Levels."],"pmcid":["PMC10978407"],"pubmed_authors":["Khajehei M","Pinthus JH","Subramony Gayathri V","Margel D","Duivenvoorden WCM","Duceppe E","Yousef S","Naeim M","Hopmans S","Devereaux PJ","Ber Y","Popovic S","Heels-Ansdell D"],"additional_accession":[]},"is_claimable":false,"name":"Follicle-Stimulating Hormone Exacerbates Cardiovascular Disease in the Presence of Low or Castrate Testosterone Levels.","description":"Low testosterone (T), common in aging men, associates with cardiovascular disease. We investigated whether follicle-stimulating hormone (FSH), which is affected by T, modulates the cardiovascular effects associated with low T or castration. FSHβ<sup>-/-</sup>:low-density lipoprotein receptor (LDLR)<sup>-/-</sup> mice, untreated or castrated (orchiectomy, gonadotropin-releasing hormone agonist or antagonist), demonstrated significantly less atherogenesis compared with similarly treated LDLR<sup>-/-</sup> mice, but not following FSH delivery. Smaller plaque burden in LDLR<sup>-/-</sup> mice receiving gonadotropin-releasing hormone antagonists vs agonists were nullified in FSHβ<sup>-/-</sup>:LDLR<sup>-/-</sup> mice. Atherosclerotic and necrotic plaque size and macrophage infiltration correlated with serum FSH/T. In patients with prostate cancer, FSH/T following androgen-deprivation therapy initiation predicted cardiovascular events. FSH facilitates cardiovascular disease when T is low or eliminated.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2025-04-25T18:56:46.774Z","creation":"2025-04-06T07:46:07.047Z"},"accession":"S-EPMC10978407","cross_references":{"pubmed":["38559622"],"doi":["10.1016/j.jacbts.2023.10.010"]}}