{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hao Q"],"funding":["Priority Academic Program of Henan Higher Education Institutions","Young and Middle-Aged Health Science and Technology Innovation Talent Project of Henan Province","National Natural Science Foundation of China"],"pagination":["57"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10978675"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(1)"],"pubmed_abstract":["Acute myeloid leukemia (AML) is a heterogeneous disease with a poor prognosis. The current risk stratification system is essential but remains insufficient to select the best schedules. Cysteine-rich protein 1 (CSRP1) is a member of the CSRP family and associated with poor clinicopathological features in many tumors. This study aimed to explore the clinical significance and molecular mechanisms of cysteine- and glycine-rich protein 1 (CSRP1) in AML. RT-qPCR was used to detect the relative expression of CSRP1 in our clinical cohort. Functional enrichment analysis of CSRP1-related differentially expressed genes was carried out by GO/KEGG enrichment analysis, immune cell infiltration analysis, and protein-protein interaction (PPI) network. The OncoPredict algorithm was implemented to explore "],"journal":["Clinical and experimental medicine"],"pubmed_title":["Cysteine- and glycine-rich protein 1 predicts prognosis and therapy response in patients with acute myeloid leukemia."],"pmcid":["PMC10978675"],"funding_grant_id":["YXKC2021011","81800137","23A320035"],"pubmed_authors":["Sun L","Liu Y","Jiang Z","Shi L","Hao Q","Yang L","Wang C","Wang S","Chen Y"],"additional_accession":[]},"is_claimable":false,"name":"Cysteine- and glycine-rich protein 1 predicts prognosis and therapy response in patients with acute myeloid leukemia.","description":"Acute myeloid leukemia (AML) is a heterogeneous disease with a poor prognosis. The current risk stratification system is essential but remains insufficient to select the best schedules. Cysteine-rich protein 1 (CSRP1) is a member of the CSRP family and associated with poor clinicopathological features in many tumors. This study aimed to explore the clinical significance and molecular mechanisms of cysteine- and glycine-rich protein 1 (CSRP1) in AML. RT-qPCR was used to detect the relative expression of CSRP1 in our clinical cohort. Functional enrichment analysis of CSRP1-related differentially expressed genes was carried out by GO/KEGG enrichment analysis, immune cell infiltration analysis, and protein-protein interaction (PPI) network. The OncoPredict algorithm was implemented to explore ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2026-05-29T11:21:51.844Z","creation":"2025-04-05T23:17:35.613Z"},"accession":"S-EPMC10978675","cross_references":{"pubmed":["38546813"],"doi":["10.1007/s10238-023-01269-w"]}}