{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14(1)"],"submitter":["Ganjeh MS"],"pubmed_abstract":["α-Glucosidase inhibitors have emerged as crucial agents in the management of type 2 diabetes mellitus. In the present study, a new series of coumarin-linked 2-phenylbenzimidazole derivatives 5a-m was designed, synthesized, and evaluated as anti-α-glucosidase agents. Among these derivatives, compound 5k (IC<sub>50</sub> = 10.8 µM) exhibited a significant inhibitory activity in comparison to the positive control acarbose (IC<sub>50</sub> = 750.0 µM). Through kinetic analysis, it was revealed that compound 5k exhibited a competitive inhibition pattern against α-glucosidase. To gain insights into the interactions between the title compounds and α-glucosidase molecular docking was employed. The obtained results highlighted crucial interactions that contribute to the inhibitory activities of the compounds against α-glucosidase. These derivatives show immense potential as promising starting points for developing novel α-glucosidase inhibitors."],"journal":["Scientific reports"],"pagination":["7408"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10978946"],"repository":["biostudies-literature"],"pubmed_title":["Coumarin linked to 2-phenylbenzimidazole derivatives as potent α-glucosidase inhibitors."],"pmcid":["PMC10978946"],"pubmed_authors":["Mazlomifar A","Ganjeh MS","Shahvelayti AS","Moghaddam SK"],"additional_accession":[]},"is_claimable":false,"name":"Coumarin linked to 2-phenylbenzimidazole derivatives as potent α-glucosidase inhibitors.","description":"α-Glucosidase inhibitors have emerged as crucial agents in the management of type 2 diabetes mellitus. In the present study, a new series of coumarin-linked 2-phenylbenzimidazole derivatives 5a-m was designed, synthesized, and evaluated as anti-α-glucosidase agents. Among these derivatives, compound 5k (IC<sub>50</sub> = 10.8 µM) exhibited a significant inhibitory activity in comparison to the positive control acarbose (IC<sub>50</sub> = 750.0 µM). Through kinetic analysis, it was revealed that compound 5k exhibited a competitive inhibition pattern against α-glucosidase. To gain insights into the interactions between the title compounds and α-glucosidase molecular docking was employed. The obtained results highlighted crucial interactions that contribute to the inhibitory activities of the compounds against α-glucosidase. These derivatives show immense potential as promising starting points for developing novel α-glucosidase inhibitors.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2025-04-26T11:24:59.365Z","creation":"2025-04-06T13:42:16.173Z"},"accession":"S-EPMC10978946","cross_references":{"pubmed":["38548784"],"doi":["10.1038/s41598-024-57673-z"]}}