{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chikui T"],"funding":["Ministry of Education, Culture, Sports, Science and Technology"],"pagination":["20584601241244777"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10979534"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(3)"],"pubmed_abstract":["<h4>Background</h4>Diffusion-weighted imaging (DWI) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) are widely used in the orofacial region. Furthermore, quantitative analyses have proven useful. However, a few reports have described the correlation between DWI-derived parameters and DCE-MRI-derived parameters, and the results have been controversial.<h4>Purpose</h4>To evaluate the correlation among parameters obtained by DWI and DCE-MRI and to compare them between benign and malignant lesions.<h4>Material and methods</h4>Fifty orofacial lesions were analysed. The apparent diffusion coefficient (ADC), true diffusion coefficient (D), pseudodiffusion coefficient (D*) and perfusion fraction (f) were estimated by DWI. For DCE-MRI, TK model analysis was performed to estimate physiological parameters, for example, the influx forward volume transfer constant into the extracellular-extravascular space (EES) (K<sup>trans</sup>) and fractional volumes of EES and plasma components (ve and vp).<h4>Results</h4>Both ADC and D showed a moderate positive correlation with ve (ρ = 0.640 and 0.645, respectively). K<sup>trans</sup> showed a marginally weak correlation with f (ρ = 0.296), while vp was not correlated with f or D*; therefore, IVIM perfusion-related parameters and TK model perfusion-related parameters were not straightforward. Both D and ve yielded high diagnostic power between benign lesions and malignant tumours with areas under the curve (AUCs) of 0.830 and 0.782, respectively.<h4>Conclusion</h4>Both D and ve were reliable parameters that were useful for the differential diagnosis. In addition, the true diffusion coefficient (D) was affected by the fractional volume of EES."],"journal":["Acta radiologica open"],"pubmed_title":["Correlation between diffusion-weighted image-derived parameters and dynamic contrast-enhanced magnetic resonance imaging-derived parameters in the orofacial region."],"pmcid":["PMC10979534"],"funding_grant_id":["Grant-in-Aid for Scientific Research (C) 18K09770"],"pubmed_authors":["Chikui T","Kiyoshima T","Togao O","Yoshiura K","Ohga M","Kawano S","Kami Y"],"additional_accession":[]},"is_claimable":false,"name":"Correlation between diffusion-weighted image-derived parameters and dynamic contrast-enhanced magnetic resonance imaging-derived parameters in the orofacial region.","description":"<h4>Background</h4>Diffusion-weighted imaging (DWI) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) are widely used in the orofacial region. Furthermore, quantitative analyses have proven useful. However, a few reports have described the correlation between DWI-derived parameters and DCE-MRI-derived parameters, and the results have been controversial.<h4>Purpose</h4>To evaluate the correlation among parameters obtained by DWI and DCE-MRI and to compare them between benign and malignant lesions.<h4>Material and methods</h4>Fifty orofacial lesions were analysed. The apparent diffusion coefficient (ADC), true diffusion coefficient (D), pseudodiffusion coefficient (D*) and perfusion fraction (f) were estimated by DWI. For DCE-MRI, TK model analysis was performed to estimate physiological parameters, for example, the influx forward volume transfer constant into the extracellular-extravascular space (EES) (K<sup>trans</sup>) and fractional volumes of EES and plasma components (ve and vp).<h4>Results</h4>Both ADC and D showed a moderate positive correlation with ve (ρ = 0.640 and 0.645, respectively). K<sup>trans</sup> showed a marginally weak correlation with f (ρ = 0.296), while vp was not correlated with f or D*; therefore, IVIM perfusion-related parameters and TK model perfusion-related parameters were not straightforward. Both D and ve yielded high diagnostic power between benign lesions and malignant tumours with areas under the curve (AUCs) of 0.830 and 0.782, respectively.<h4>Conclusion</h4>Both D and ve were reliable parameters that were useful for the differential diagnosis. In addition, the true diffusion coefficient (D) was affected by the fractional volume of EES.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2025-04-22T08:21:28.457Z","creation":"2025-04-22T08:21:28.457Z"},"accession":"S-EPMC10979534","cross_references":{"pubmed":["38559449"],"doi":["10.1177/20584601241244777"]}}