biostudies-literatureKortas JANarodowym Centrum Nauki300https://www.ebi.ac.uk/biostudies/studies/S-EPMC10979559biostudies-literatureUnknown24(1)<h4>Background and aims</h4>This study evaluated whether stored iron determines the adaptive response induced by Nordic walking (NW) training combined with 10 hours' time-restricted eating (TRE) in older adults.<h4>Trial design and methods</h4>Twenty-four participants underwent 12-week NW training supported by 10 h of TRE. The group was divided due to baseline ferritin concentration low < 75 ng/ml (LF) and high level ≥ 75 ng/ml (HF). Body composition, physical fitness and blood collection were assessed at baseline and post-intervention.<h4>Results</h4>NW + TRE induced a statistically significant decrease in ferritin levels in all participants (p = 0.01). Additionally, statistically significant intergroup differences in the LF vs. HF in the reduction of serum ferritin levels (p = 0.04) were observed. The procedure NW + TRE diminished HbA1c levels (p < 0.01) and glucose in all participants (p = 0.05). The range of HbA1c drop was more pronounced among those participants who experienced a greater decrease in the stored iron (p = 0.04, [Formula: see text]=0.17, F=4.59). Greater changes in body weight and percent of body fat were recorded in the HF group (for both p<0.01).<h4>Conclusion</h4>Body iron stores determine the effects of a 12-week NW + TRE intervention on serum ferritin. The changes in HbA1c are more pronounced in subjects with a higher decrease in serum ferritin.<h4>Trial registration</h4>All experimental protocols were approved by the Bioethical Committee of the Regional Medical Society in Gdansk, Poland (NKBBN/330/2021) according to the Declaration of Helsinki. We confirm that all methods were carried out in accordance with relevant guidelines and regulations. The trial was registered as a clinical trial (NCT05229835, date of first registration: 14/01/2022, direct link: https://classic.<h4>Clinicaltrials</h4>gov/ct2/show/NCT05229835 ). Informed consent was obtained from all subjects.BMC geriatricsIron status determined changes in health measures induced by nordic walking with time-restricted eating in older adults- a randomised trial.PMC109795592020/37/B/NZ7/01794Flis DGalezowska GZiemann EOlszewski SKortas JARodziewicz-Flis ESwiatczak AAntosiewicz JZychowska MSoltani NReczkowicz JPrusik KJuhas UfalseIron status determined changes in health measures induced by nordic walking with time-restricted eating in older adults- a randomised trial.<h4>Background and aims</h4>This study evaluated whether stored iron determines the adaptive response induced by Nordic walking (NW) training combined with 10 hours' time-restricted eating (TRE) in older adults.<h4>Trial design and methods</h4>Twenty-four participants underwent 12-week NW training supported by 10 h of TRE. The group was divided due to baseline ferritin concentration low < 75 ng/ml (LF) and high level ≥ 75 ng/ml (HF). Body composition, physical fitness and blood collection were assessed at baseline and post-intervention.<h4>Results</h4>NW + TRE induced a statistically significant decrease in ferritin levels in all participants (p = 0.01). Additionally, statistically significant intergroup differences in the LF vs. HF in the reduction of serum ferritin levels (p = 0.04) were observed. The procedure NW + TRE diminished HbA1c levels (p < 0.01) and glucose in all participants (p = 0.05). The range of HbA1c drop was more pronounced among those participants who experienced a greater decrease in the stored iron (p = 0.04, [Formula: see text]=0.17, F=4.59). Greater changes in body weight and percent of body fat were recorded in the HF group (for both p<0.01).<h4>Conclusion</h4>Body iron stores determine the effects of a 12-week NW + TRE intervention on serum ferritin. The changes in HbA1c are more pronounced in subjects with a higher decrease in serum ferritin.<h4>Trial registration</h4>All experimental protocols were approved by the Bioethical Committee of the Regional Medical Society in Gdansk, Poland (NKBBN/330/2021) according to the Declaration of Helsinki. We confirm that all methods were carried out in accordance with relevant guidelines and regulations. The trial was registered as a clinical trial (NCT05229835, date of first registration: 14/01/2022, direct link: https://classic.<h4>Clinicaltrials</h4>gov/ct2/show/NCT05229835 ). Informed consent was obtained from all subjects.2024-01-01T00:00:00Z2024 Mar2025-04-05T14:44:02.322Z2025-04-05T14:44:02.322ZS-EPMC109795593855369010.1186/s12877-024-04876-8