{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ariizumi T"],"funding":["Ministry of Health, Labour and Welfare","Moonshot Research and Development Program","Japan Agency for Medical Research and Development","Japan Society for the Promotion of Science"],"pagination":["e1012101"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10980201"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(3)"],"pubmed_abstract":["Emerging and reemerging tick-borne virus infections caused by orthonairoviruses (family Nairoviridae), which are genetically distinct from Crimean-Congo hemorrhagic fever virus, have been recently reported in East Asia. Here, we have established a mouse infection model using type-I/II interferon receptor-knockout mice (AG129 mice) both for a better understanding of the pathogenesis of these infections and validation of antiviral agents using Yezo virus (YEZV), a novel orthonairovirus causing febrile illnesses associated with tick bites in Japan and China. YEZV-inoculated AG129 mice developed hepatitis with body weight loss and died by 6 days post infection. Blood biochemistry tests showed elevated liver enzyme levels, similar to YEZV-infected human patients. AG129 mice treated with favipiravir survived lethal YEZV infection, demonstrating the anti-YEZV effect of this drug. The present mouse model will help us better understand the pathogenicity of the emerging tick-borne orthonairoviruses and the development of specific antiviral agents for their treatment."],"journal":["PLoS pathogens"],"pubmed_title":["Establishment of a lethal mouse model of emerging tick-borne orthonairovirus infections."],"pmcid":["PMC10980201"],"funding_grant_id":["JP23fk0108644, JP23fk0108625, JP23jf0126002","JP23H02373, JP23K20041","JP21wm0125008","23HA2010","223fa627005h0001","JP22fk0108637","JPMJMS2025"],"pubmed_authors":["Sawa H","Tabata K","Sasaki M","Matsuno K","Ariizumi T","Orba Y","Kobayashi H","Itakura Y","Hall WW"],"additional_accession":[]},"is_claimable":false,"name":"Establishment of a lethal mouse model of emerging tick-borne orthonairovirus infections.","description":"Emerging and reemerging tick-borne virus infections caused by orthonairoviruses (family Nairoviridae), which are genetically distinct from Crimean-Congo hemorrhagic fever virus, have been recently reported in East Asia. Here, we have established a mouse infection model using type-I/II interferon receptor-knockout mice (AG129 mice) both for a better understanding of the pathogenesis of these infections and validation of antiviral agents using Yezo virus (YEZV), a novel orthonairovirus causing febrile illnesses associated with tick bites in Japan and China. YEZV-inoculated AG129 mice developed hepatitis with body weight loss and died by 6 days post infection. Blood biochemistry tests showed elevated liver enzyme levels, similar to YEZV-infected human patients. AG129 mice treated with favipiravir survived lethal YEZV infection, demonstrating the anti-YEZV effect of this drug. The present mouse model will help us better understand the pathogenicity of the emerging tick-borne orthonairoviruses and the development of specific antiviral agents for their treatment.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2025-04-22T21:34:47.363Z","creation":"2025-04-06T03:34:48.402Z"},"accession":"S-EPMC10980201","cross_references":{"pubmed":["38502642"],"doi":["10.1371/journal.ppat.1012101"]}}