biostudies-literatureHo PCNEI NIH HHSNational Eye InstituteNIA NIH HHSAlzheimer&apos;s AssociationKorea Brain Research InstituteAlzheimer's AssociationNational Institute on Aging2058-2071https://www.ebi.ac.uk/biostudies/studies/S-EPMC10984480biostudies-literatureUnknown20(3)<h4>Introduction</h4>Clinical research in Alzheimer's disease (AD) lacks cohort diversity despite being a global health crisis. The Asian Cohort for Alzheimer's Disease (ACAD) was formed to address underrepresentation of Asians in research, and limited understanding of how genetics and non-genetic/lifestyle factors impact this multi-ethnic population.<h4>Methods</h4>The ACAD started fully recruiting in October 2021 with one central coordination site, eight recruitment sites, and two analysis sites. We developed a comprehensive study protocol for outreach and recruitment, an extensive data collection packet, and a centralized data management system, in English, Chinese, Korean, and Vietnamese.<h4>Results</h4>ACAD has recruited 606 participants with an additional 900 expressing interest in eAlzheimer's & dementia : the journal of the Alzheimer's AssociationAsian Cohort for Alzheimer's Disease (ACAD) pilot study on genetic and non-genetic risk factors for Alzheimer's disease among Asian Americans and Canadians.PMC10984480R01 AG083926K23 AG062750P01 AG019724R24 AG063718R24AG063718R21 AG068757K24 AG045333U19 AG079774U24 AG021886P30 AG066462U24AG021886ALZ‐NAN‐22‐928181R01AG083926R03 AG061439R01AG083840R56 AG069130R21AG077649U19 AG068753R61 AG083582UH2 AG083258K23AG062750R01 AG080469R61AG083582U10 EY017337P30 AG062422R01 AG072562U10EY017337R21AG068757P30 AG062429U19AG079774AACSFD‐22‐972143R01AG080469P30 AG06653023‐BR‐03‐05P30AG062422ALZ-NAN-22-928181R01 AG062588U19AG068753R01 AG083840UH2AG083258R21 AG077649AACSFD-22-972143Seo EHChui HWong ECReyes-Dumeyer DDeng MClark DSchellenberg GDKukull WATzuang MPeavy GMAu RVarma RSong YEHong THRevta CVardarajan BNJun GRLi CXie YHo PCJoo YLi DWang LSLupo JLForoud TChen FZeng XKang YYu WHLu ALi MChoi YBBooth BLi XRamirez VTartaglia MCYau EBLiu CLDage JLLam ETorres MHsiung GRJiang LLiu LKim HKim KLee KKim ESLee HFeldman HHPfleuger SEYu VChow TWMcCallum JChou SSt George-Hyslop PLieu KTee BLQian JTian LMayeux RLee WPFaber KMKirsch MYang HSGu YCantwell LBTa Park VMYokoyama JSRosen HHenderson VWNguyen KHwang LJVo NKuzma ABQian WPotter ZDYi IMei DLiu CRuss KALanata SCfalseAsian Cohort for Alzheimer's Disease (ACAD) pilot study on genetic and non-genetic risk factors for Alzheimer's disease among Asian Americans and Canadians.<h4>Introduction</h4>Clinical research in Alzheimer's disease (AD) lacks cohort diversity despite being a global health crisis. The Asian Cohort for Alzheimer's Disease (ACAD) was formed to address underrepresentation of Asians in research, and limited understanding of how genetics and non-genetic/lifestyle factors impact this multi-ethnic population.<h4>Methods</h4>The ACAD started fully recruiting in October 2021 with one central coordination site, eight recruitment sites, and two analysis sites. We developed a comprehensive study protocol for outreach and recruitment, an extensive data collection packet, and a centralized data management system, in English, Chinese, Korean, and Vietnamese.<h4>Results</h4>ACAD has recruited 606 participants with an additional 900 expressing interest in e2024-01-01T00:00:00Z2024 Mar2026-07-16T12:14:41.577Z2025-04-05T22:30:47.865ZS-EPMC109844803821505310.1002/alz.13611