{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Pan K"],"funding":["NICHD NIH HHS","University of North Carolina","NIA NIH HHS","NIEHS NIH HHS","NHLBI NIH HHS","Health Studies Fund, Department of Family and Preventive Medicine, University of Utah","National Heart, Lung, and Blood Institute","National Center on Minority Health and Health Disparities","Northwestern University","Louisiana Clinical and Translational Science Center","Time to Pregnancy in Couples of Proven Fecundity Study","National Institute of Dental and Craniofacial Research","San Diego State University","National Science Foundation","National Institute of Neurological Disorders and Stroke","National Institute of Environmental Health Sciences","National Institute of Diabetes and Digestive and Kidney Diseases","Hispanic Community Health Study/Study of Latinos","National Institute on Deafness and Other Communication Disorders","NIH","National Institute of General Medical Sciences","University of Miami","Home Observation of Periconceptional Exposures","Coronary Artery Risk Development in Young Adults","Office of Dietary Supplements","NIDDK NIH HHS","Albert Einstein College of Medicine","National Institute of Child Health and Human Development","NIGMS NIH HHS"],"pagination":["2033-2049"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10988223"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["192(12)"],"pubmed_abstract":["The Preconception Period Analysis of Risks and Exposures Influencing Health and Development (PrePARED) Consortium creates a novel resource for addressing preconception health by merging data from numerous cohort studies. In this paper, we describe our data harmonization methods and results. Individual-level data from 12 prospective studies were pooled. The crosswalk-cataloging-harmonization procedure was used. The index pregnancy was defined as the first postbaseline pregnancy lasting more than 20 weeks. We assessed heterogeneity across studies by comparing preconception characteristics in different types of studies. The pooled data set included 114,762 women, and 25,531 (22%) reported at least 1 pregnancy of more than 20 weeks' gestation during the study period. Babies from the index pregnancies were delivered between 1976 and 2021 (median, 2008), at a mean maternal age of 29.7 (standard deviation, 4.6) years. Before the index pregnancy, 60% of women were nulligravid, 58% had a college degree or more, and 37% were overweight or obese. Other harmonized variables included race/ethnicity, household income, substance use, chronic conditions, and perinatal outcomes. Participants from pregnancy-planning studies had more education and were healthier. The prevalence of preexisting medical conditions did not vary substantially based on whether studies relied on self-reported data. Use of harmonized data presents opportunities to study uncommon preconception risk factors and pregnancy-related events. This harmonization effort laid the groundwork for future analyses and additional data harmonization."],"journal":["American journal of epidemiology"],"pubmed_title":["Large-Scale Data Harmonization Across Prospective Studies."],"pmcid":["PMC10988223"],"funding_grant_id":["P30 ES013508","R21 HD072326","R01HD032194","R01 HD086742","R01AG016592","R01 DK090047","R01 AG016592","1R01ES020488-01","HHSN268201800004I","N01-HC65233","R01 DK106201","HHSN268201800006I","N01-HC65234","K23 HD001479","N01-HC65235","R01 HD105863","N01-HC65236","N01-HC65237","R01 HD069587","R01 HL121230","N01HC65236","R01 ES020488","N01HC65237","N01HC65234","R01AG041200","N01HC65235","Z01ES103333","N01HC65233","R01 ES028923","R01 ES029951","NSF1914792","P50 HL015103","R01HD069587","U54 GM104940","1K23 HD0147901-01A1","P50HL015103","HHSN268201800005I","R01 AG041200","HHSN268201800007I","HHSN267200603426","R01HL121230","HHSN268201800003I","U01 HL145386","R01 HD032194","K01 DK059944","HHSN267200603424","R21 HD094322","HHSN267200603423"],"pubmed_authors":["Haggerty CL","Hart JE","Ley SH","Schliep K","Charlton BM","Jukic AM","Sotres-Alvarez D","Mumford SL","Yeung E","Chavarro JE","Mishra GD","Schisterman EF","Wilcox AJ","Gunderson EP","Shaffer JG","Bazzano LA","Stanford JB","Cordero C","Wise LA","Pan K","Betha K","Harville EW"],"additional_accession":[]},"is_claimable":false,"name":"Large-Scale Data Harmonization Across Prospective Studies.","description":"The Preconception Period Analysis of Risks and Exposures Influencing Health and Development (PrePARED) Consortium creates a novel resource for addressing preconception health by merging data from numerous cohort studies. In this paper, we describe our data harmonization methods and results. Individual-level data from 12 prospective studies were pooled. The crosswalk-cataloging-harmonization procedure was used. The index pregnancy was defined as the first postbaseline pregnancy lasting more than 20 weeks. We assessed heterogeneity across studies by comparing preconception characteristics in different types of studies. The pooled data set included 114,762 women, and 25,531 (22%) reported at least 1 pregnancy of more than 20 weeks' gestation during the study period. Babies from the index pregnancies were delivered between 1976 and 2021 (median, 2008), at a mean maternal age of 29.7 (standard deviation, 4.6) years. Before the index pregnancy, 60% of women were nulligravid, 58% had a college degree or more, and 37% were overweight or obese. Other harmonized variables included race/ethnicity, household income, substance use, chronic conditions, and perinatal outcomes. Participants from pregnancy-planning studies had more education and were healthier. The prevalence of preexisting medical conditions did not vary substantially based on whether studies relied on self-reported data. Use of harmonized data presents opportunities to study uncommon preconception risk factors and pregnancy-related events. This harmonization effort laid the groundwork for future analyses and additional data harmonization.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Nov","modification":"2025-04-04T23:54:14.477Z","creation":"2025-04-04T23:54:14.477Z"},"accession":"S-EPMC10988223","cross_references":{"pubmed":["37403415"],"doi":["10.1093/aje/kwad153"]}}