{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Leon-Ferre RA"],"funding":["NCATS NIH HHS","NCI NIH HHS"],"pagination":["1135-1144"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10988354"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["331(13)"],"pubmed_abstract":["<h4>Importance</h4>The association of tumor-infiltrating lymphocyte (TIL) abundance in breast cancer tissue with cancer recurrence and death in patients with early-stage triple-negative breast cancer (TNBC) who are not treated with adjuvant or neoadjuvant chemotherapy is unclear.<h4>Objective</h4>To study the association of TIL abundance in breast cancer tissue with survival among patients with early-stage TNBC who were treated with locoregional therapy but no chemotherapy.<h4>Design, setting, and participants</h4>Retrospective pooled analysis of individual patient-level data from 13 participating centers in North America (Rochester, Minnesota; Vancouver, British Columbia, Canada), Europe (Paris, Lyon, and Villejuif, France; Amsterdam and Rotterdam, the Netherlands; Milan, Padova, and Geno"],"journal":["JAMA"],"pubmed_title":["Tumor-Infiltrating Lymphocytes in Triple-Negative Breast Cancer."],"pmcid":["PMC10988354"],"funding_grant_id":["P50 CA116201","KL2 TR002379"],"pubmed_authors":["Kok M","Michiels S","Criscitiello C","Shimoi T","Jules-Clement G","Lambertini M","Linderholm B","Jonas SF","Curigliano G","Kim SB","Lee HJ","Riaz N","Yazaki S","Bataillon G","Yoshida M","Carter JM","Timmermans AM","Nielsen TO","Chia S","Vincent-Salomon A","Andre F","International Immuno-Oncology Biomarker Working Group","van Deurzen CHM","Linn SC","Suman VJ","Dieci MV","Salgado R","Martens JWM","Loi S","Goetz MP","de Jong V","Leon-Ferre RA","Cockenpot V","Leung S"],"additional_accession":[]},"is_claimable":false,"name":"Tumor-Infiltrating Lymphocytes in Triple-Negative Breast Cancer.","description":"<h4>Importance</h4>The association of tumor-infiltrating lymphocyte (TIL) abundance in breast cancer tissue with cancer recurrence and death in patients with early-stage triple-negative breast cancer (TNBC) who are not treated with adjuvant or neoadjuvant chemotherapy is unclear.<h4>Objective</h4>To study the association of TIL abundance in breast cancer tissue with survival among patients with early-stage TNBC who were treated with locoregional therapy but no chemotherapy.<h4>Design, setting, and participants</h4>Retrospective pooled analysis of individual patient-level data from 13 participating centers in North America (Rochester, Minnesota; Vancouver, British Columbia, Canada), Europe (Paris, Lyon, and Villejuif, France; Amsterdam and Rotterdam, the Netherlands; Milan, Padova, and Geno","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Apr","modification":"2025-04-18T13:47:02.25Z","creation":"2025-04-06T23:38:14.888Z"},"accession":"S-EPMC10988354","cross_references":{"pubmed":["38563834"],"doi":["10.1001/jama.2024.3056"]}}