biostudies-literatureSugawara JJapan Society for the Promotion of Science1057-1065https://www.ebi.ac.uk/biostudies/studies/S-EPMC10988493biostudies-literatureUnknown108(8)<h4>New findings</h4>What is the central question of this study? High-intensity interval exercise (HIIE) is recommended for its favourable haemodynamic stimulation, but excessive haemodynamic fluctuations may stress the brain: is the cerebral vasculature protected against exaggerated systemic blood flow fluctuation during HIIE? What is the main finding and its importance? Time- and frequency-domain indices of aortic-cerebral pulsatile transition were lowered during HIIE. The findings suggest that the arterial system to the cerebral vasculature may attenuate pulsatile transition during HIIE as a defence mechanism against pulsatile fluctuation for the cerebral vasculature.<h4>Abstract</h4>High-intensity interval exercise (HIIE) is recommended because it provides favourable haemodynamic stimuExperimental physiologyAttenuated pulsatile transition to the cerebral vasculature during high-intensity interval exercise in young healthy men.PMC1098849315J0402318H0315617H021862670202915K1267615H0309815KK035820H04086Hashimoto TSugawara JOgoh STsukamoto HSecher NHfalseAttenuated pulsatile transition to the cerebral vasculature during high-intensity interval exercise in young healthy men.<h4>New findings</h4>What is the central question of this study? High-intensity interval exercise (HIIE) is recommended for its favourable haemodynamic stimulation, but excessive haemodynamic fluctuations may stress the brain: is the cerebral vasculature protected against exaggerated systemic blood flow fluctuation during HIIE? What is the main finding and its importance? Time- and frequency-domain indices of aortic-cerebral pulsatile transition were lowered during HIIE. The findings suggest that the arterial system to the cerebral vasculature may attenuate pulsatile transition during HIIE as a defence mechanism against pulsatile fluctuation for the cerebral vasculature.<h4>Abstract</h4>High-intensity interval exercise (HIIE) is recommended because it provides favourable haemodynamic stimu2023-01-01T00:00:00Z2023 Aug2025-04-05T15:08:06.738Z2025-04-05T15:08:06.738ZS-EPMC109884933730908410.1113/EP091119