{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Thomas CE"],"funding":["Intramural NIH HHS","Austrian Research Funding Agency","World Health Organization","NIA NIH HHS","German Research Council","Junta de Castilla y León","NHLBI NIH HHS","National Institutes of Health","International Agency for Research on Cancer","Spanish Association Against Cancer","German Federal Ministry of Education and Research","Herzfelder&apos;sche Familienstiftung","American Cancer Society","Instituto de Salud Carlos III","NIDDK NIH HHS","Victorian Cancer Agency","NHGRI NIH HHS","NCI NIH HHS","Australian NHMRC","NIH HHS","WHI NIH HHS"],"pagination":["534-546"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10990777"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["33(4)"],"pubmed_abstract":["<h4>Background</h4>The genotoxin colibactin causes a tumor single-base substitution (SBS) mutational signature, SBS88. It is unknown whether epidemiologic factors' association with colorectal cancer risk and survival differs by SBS88.<h4>Methods</h4>Within the Genetic Epidemiology of Colorectal Cancer Consortium and Colon Cancer Family Registry, we measured SBS88 in 4,308 microsatellite stable/microsatellite instability low tumors. Associations of epidemiologic factors with colorectal cancer risk by SBS88 were assessed using multinomial regression (N = 4,308 cases, 14,192 controls; cohort-only cases N = 1,911), and with colorectal cancer-specific survival using Cox proportional hazards regression (N = 3,465 cases).<h4>Results</h4>392 (9%) tumors were SBS88 positive. Among all cases, the hi"],"journal":["Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology"],"pubmed_title":["Epidemiologic Factors in Relation to Colorectal Cancer Risk and Survival by Genotoxic Colibactin Mutational Signature."],"pmcid":["PMC10990777"],"funding_grant_id":["U01 CA137088","K01 DK120742","Z01 CP 010200","R01 CA488857","CA107333","P01 CA087969","U01 CA176726","CH 117/1-1","HHSN261201000032C","U01CA261961","U01 CA261961","R21 CA191312","PI09-1286","509348","R01 CA151993","R35 CA253185","HHSN268201100001I","LE22A10-2","R01 CA244588","HHSN268201100001C","KL 2354/3-1","U01 HG004438","R01 CA137178","209057","MCRF18005","K01DK120742","HE 5998/2-1","001","BR 1704/6-3","BR 1704/6-1","S10OD028685","P30 CA015083","01ER0815","HHSN268201100002I","01ER0814","BR 1704/6-4","HHSN268201100002C","HHSN268201100046C","01ER1505B","01ER1505A","UM1 CA186107","R01 CA206279","R01 CA107333","R35 CA197735","U01 HG004446","U01 CA167552","U01 CA167551","GCTRA18022MORE","NIH U01 HG004446","T32 CA009168","Z01 CP010200","HHSN268201100003C","HHSN268201700006C","251553","UM1 CA167552","504711","COST Action BM1206","R37 CA246175","HHSN268201200008I","S10 OD028685","P01 CA055075","HHSN268201100003I","R01 CA059045","829675","HHSN268201200008C","P20 CA252733","U01 CA164930","R01 CA215151","R01 CA201407","P30 CA015704","RO 2270/8-1","L70 CA284301","R37CA246175","HHSN268201100004C","PI14-613","R01 CA068535","01KH0404","HO 5117/2-1","T32 CA094880","HHSN271201100004C","HHSN268201100004I","GEI U01 HG 004438"],"pubmed_authors":["Qu C","Um CY","Huang WY","Toland AE","Trinh QM","Berndt SI","Zaidi SH","Drew DA","Phipps AI","Thomas CE","Murphy N","Song M","Huyghe JR","Peters U","Gunter MJ","Buchanan DD","Newcomb PA","Melaku YA","Chan AT","Obon-Santacana M","Giannakis M","Lynch BM","French AJ","Steinfelder RS","Sun W","Ugai T","Van Guelpen B","Ogino S","Figueiredo JC","Gruber SB","Harrison TA","Campbell PT","Moreno V","Hullar MA","Cao Y","Jenkins MA","Gsur A","Hsu L","Boardman LA","Newton CC","Aglago EK","Georgeson P","Goode EL","Hoffmeister M","Nowak JA"],"additional_accession":[]},"is_claimable":false,"name":"Epidemiologic Factors in Relation to Colorectal Cancer Risk and Survival by Genotoxic Colibactin Mutational Signature.","description":"<h4>Background</h4>The genotoxin colibactin causes a tumor single-base substitution (SBS) mutational signature, SBS88. It is unknown whether epidemiologic factors' association with colorectal cancer risk and survival differs by SBS88.<h4>Methods</h4>Within the Genetic Epidemiology of Colorectal Cancer Consortium and Colon Cancer Family Registry, we measured SBS88 in 4,308 microsatellite stable/microsatellite instability low tumors. Associations of epidemiologic factors with colorectal cancer risk by SBS88 were assessed using multinomial regression (N = 4,308 cases, 14,192 controls; cohort-only cases N = 1,911), and with colorectal cancer-specific survival using Cox proportional hazards regression (N = 3,465 cases).<h4>Results</h4>392 (9%) tumors were SBS88 positive. Among all cases, the hi","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Apr","modification":"2025-04-04T01:03:19.633Z","creation":"2025-04-04T01:03:19.633Z"},"accession":"S-EPMC10990777","cross_references":{"pubmed":["38252034"],"doi":["10.1158/1055-9965.EPI-23-0600","10.1158/1055-9965.epi-23-0600"]}}