biostudies-literatureThomas CEIntramural NIH HHSAustrian Research Funding AgencyWorld Health OrganizationNIA NIH HHSGerman Research CouncilJunta de Castilla y LeónNHLBI NIH HHSNational Institutes of HealthInternational Agency for Research on CancerSpanish Association Against CancerGerman Federal Ministry of Education and ResearchHerzfelder&apos;sche FamilienstiftungAmerican Cancer SocietyInstituto de Salud Carlos IIINIDDK NIH HHSVictorian Cancer AgencyNHGRI NIH HHSNCI NIH HHSAustralian NHMRCNIH HHSWHI NIH HHS534-546https://www.ebi.ac.uk/biostudies/studies/S-EPMC10990777biostudies-literatureUnknown33(4)<h4>Background</h4>The genotoxin colibactin causes a tumor single-base substitution (SBS) mutational signature, SBS88. It is unknown whether epidemiologic factors' association with colorectal cancer risk and survival differs by SBS88.<h4>Methods</h4>Within the Genetic Epidemiology of Colorectal Cancer Consortium and Colon Cancer Family Registry, we measured SBS88 in 4,308 microsatellite stable/microsatellite instability low tumors. Associations of epidemiologic factors with colorectal cancer risk by SBS88 were assessed using multinomial regression (N = 4,308 cases, 14,192 controls; cohort-only cases N = 1,911), and with colorectal cancer-specific survival using Cox proportional hazards regression (N = 3,465 cases).<h4>Results</h4>392 (9%) tumors were SBS88 positive. Among all cases, the hiCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive OncologyEpidemiologic Factors in Relation to Colorectal Cancer Risk and Survival by Genotoxic Colibactin Mutational Signature.PMC10990777U01 CA137088K01 DK120742Z01 CP 010200R01 CA488857CA107333P01 CA087969U01 CA176726CH 117/1-1HHSN261201000032CU01CA261961U01 CA261961R21 CA191312PI09-1286509348R01 CA151993R35 CA253185HHSN268201100001ILE22A10-2R01 CA244588HHSN268201100001CKL 2354/3-1U01 HG004438R01 CA137178209057MCRF18005K01DK120742HE 5998/2-1001BR 1704/6-3BR 1704/6-1S10OD028685P30 CA01508301ER0815HHSN268201100002I01ER0814BR 1704/6-4HHSN268201100002CHHSN268201100046C01ER1505B01ER1505AUM1 CA186107R01 CA206279R01 CA107333R35 CA197735U01 HG004446U01 CA167552U01 CA167551GCTRA18022MORENIH U01 HG004446T32 CA009168Z01 CP010200HHSN268201100003CHHSN268201700006C251553UM1 CA167552504711COST Action BM1206R37 CA246175HHSN268201200008IS10 OD028685P01 CA055075HHSN268201100003IR01 CA059045829675HHSN268201200008CP20 CA252733U01 CA164930R01 CA215151R01 CA201407P30 CA015704RO 2270/8-1L70 CA284301R37CA246175HHSN268201100004CPI14-613R01 CA06853501KH0404HO 5117/2-1T32 CA094880HHSN271201100004CHHSN268201100004IGEI U01 HG 004438Qu CUm CYHuang WYToland AETrinh QMBerndt SIZaidi SHDrew DAPhipps AIThomas CEMurphy NSong MHuyghe JRPeters UGunter MJBuchanan DDNewcomb PAMelaku YAChan ATObon-Santacana MGiannakis MLynch BMFrench AJSteinfelder RSSun WUgai TVan Guelpen BOgino SFigueiredo JCGruber SBHarrison TACampbell PTMoreno VHullar MACao YJenkins MAGsur AHsu LBoardman LANewton CCAglago EKGeorgeson PGoode ELHoffmeister MNowak JAfalseEpidemiologic Factors in Relation to Colorectal Cancer Risk and Survival by Genotoxic Colibactin Mutational Signature.<h4>Background</h4>The genotoxin colibactin causes a tumor single-base substitution (SBS) mutational signature, SBS88. It is unknown whether epidemiologic factors' association with colorectal cancer risk and survival differs by SBS88.<h4>Methods</h4>Within the Genetic Epidemiology of Colorectal Cancer Consortium and Colon Cancer Family Registry, we measured SBS88 in 4,308 microsatellite stable/microsatellite instability low tumors. Associations of epidemiologic factors with colorectal cancer risk by SBS88 were assessed using multinomial regression (N = 4,308 cases, 14,192 controls; cohort-only cases N = 1,911), and with colorectal cancer-specific survival using Cox proportional hazards regression (N = 3,465 cases).<h4>Results</h4>392 (9%) tumors were SBS88 positive. Among all cases, the hi2024-01-01T00:00:00Z2024 Apr2025-04-04T01:03:19.633Z2025-04-04T01:03:19.633ZS-EPMC109907773825203410.1158/1055-9965.EPI-23-060010.1158/1055-9965.epi-23-0600