biostudies-literaturePedersen LNNIBIB NIH HHSNIDDK NIH HHSNIAID NIH HHSNHLBI NIH HHSNCI NIH HHSNIH HHS928-943.e5https://www.ebi.ac.uk/biostudies/studies/S-EPMC10994563biostudies-literatureUnknown4(12)<h4>Background</h4>Rapidly dividing cells are more sensitive to radiation therapy (RT) than quiescent cells. In the failing myocardium, macrophages and fibroblasts mediate collateral tissue injury, leading to progressive myocardial remodeling, fibrosis, and pump failure. Because these cells divide more rapidly than cardiomyocytes, we hypothesized that macrophages and fibroblasts would be more susceptible to lower doses of radiation and that cardiac radiation could therefore attenuate myocardial remodeling.<h4>Methods</h4>In three independent murine heart failure models, including models of metabolic stress, ischemia, and pressure overload, mice underwent 5 Gy cardiac radiation or sham treatment followed by echocardiography. Immunofluorescence, flow cytometry, and non-invasive PET imaging wMed (New York, N.Y.)Cardiac radiation improves ventricular function in mice and humans with cardiomyopathy.PMC10994563T32 CA113275R35 HL161185R01 HL155344K08 HL138262S10 OD030403P30 DK020579R35 HL145212P30 DK052574P30 DK056341P30 CA091842R01 HL163274T32 AI007163R01 HL147884T32 HL007081S10 OD028597P41 EB025815S10 OD020136Cuculich PSHugo GGuo ZLavine KWeinheimer CGrogan FZhang SOzcan MStrong LKlaas ALiu YBergom CWoodard PKDiab ARentschler SLSchwarz JKNavara RNigro JValenzuela Ripoll CCho YSamson PNg SWalls GMPedersen LNAtaran ALotfinaghsh AKovacs AKolb KMoore KReynoso FJLuehmann HCooper DRobinson CJavaheri AHeck AfalseCardiac radiation improves ventricular function in mice and humans with cardiomyopathy.<h4>Background</h4>Rapidly dividing cells are more sensitive to radiation therapy (RT) than quiescent cells. In the failing myocardium, macrophages and fibroblasts mediate collateral tissue injury, leading to progressive myocardial remodeling, fibrosis, and pump failure. Because these cells divide more rapidly than cardiomyocytes, we hypothesized that macrophages and fibroblasts would be more susceptible to lower doses of radiation and that cardiac radiation could therefore attenuate myocardial remodeling.<h4>Methods</h4>In three independent murine heart failure models, including models of metabolic stress, ischemia, and pressure overload, mice underwent 5 Gy cardiac radiation or sham treatment followed by echocardiography. Immunofluorescence, flow cytometry, and non-invasive PET imaging w2023-01-01T00:00:00Z2023 Dec2026-06-02T10:48:33.026Z2025-04-04T01:24:35.822ZS-EPMC109945633802975410.1016/j.medj.2023.10.006