{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14(1)"],"submitter":["Sornsamdang G"],"funding":["Chulabhorn Royal Academy"],"pubmed_abstract":["Behçet's disease (BD) manifests as an autoimmune disorder featuring recurrent ulcers and multi-organ involvement, influenced by genetic factors associated with both HLA and non-HLA genes, including TNF-α and ERAP1. The study investigated the susceptible alleles of both Class I and II molecules of the HLA gene in 56 Thai BD patients and 192 healthy controls through next-generation sequencing using a PacBio kit. The study assessed 56 BD patients, primarily females (58.9%), revealing diverse manifestations including ocular (41.1%), vascular (35.7%), skin (55.4%), CNS (5.4%), and GI system (10.7%) involvement. This study found associations between BD and HLA-A*26:01:01 (OR 3.285, 95% CI 1.135-9.504, P-value 0.028), HLA-B*39:01:01 (OR 6.176, 95% CI 1.428-26.712, P-value 0.015), HLA-B*51:01:01 ("],"journal":["Scientific reports"],"pagination":["7967"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC10995258"],"repository":["biostudies-literature"],"pubmed_title":["Novel genetic variants of HLA gene associated with Thai Behcet's disease (BD) patients using next generation sequencing technology."],"pmcid":["PMC10995258"],"pubmed_authors":["Limtong P","Shobana J","Chanprapaph K","Sukasem C","Sornsamdang G","Chantratita W","O-Charoen P","Chotewutmontri S"],"additional_accession":[]},"is_claimable":false,"name":"Novel genetic variants of HLA gene associated with Thai Behcet's disease (BD) patients using next generation sequencing technology.","description":"Behçet's disease (BD) manifests as an autoimmune disorder featuring recurrent ulcers and multi-organ involvement, influenced by genetic factors associated with both HLA and non-HLA genes, including TNF-α and ERAP1. The study investigated the susceptible alleles of both Class I and II molecules of the HLA gene in 56 Thai BD patients and 192 healthy controls through next-generation sequencing using a PacBio kit. The study assessed 56 BD patients, primarily females (58.9%), revealing diverse manifestations including ocular (41.1%), vascular (35.7%), skin (55.4%), CNS (5.4%), and GI system (10.7%) involvement. This study found associations between BD and HLA-A*26:01:01 (OR 3.285, 95% CI 1.135-9.504, P-value 0.028), HLA-B*39:01:01 (OR 6.176, 95% CI 1.428-26.712, P-value 0.015), HLA-B*51:01:01 (","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Apr","modification":"2025-04-18T20:13:33.04Z","creation":"2025-04-07T08:04:53.656Z"},"accession":"S-EPMC10995258","cross_references":{"pubmed":["38575661"],"doi":["10.1038/s41598-024-58254-w"]}}