biostudies-literatureMarriott RJNCATS NIH HHSNIA NIH HHSMedical Research CouncilNovo Nordisk Fonden1221-1234https://www.ebi.ac.uk/biostudies/studies/S-EPMC10995451biostudies-literatureUnknown176(9)<h4>Background</h4>Various factors modulate circulating testosterone in men, affecting interpretation of testosterone measurements.<h4>Purpose</h4>To clarify factors associated with variations in sex hormone concentrations.<h4>Data sources</h4>Systematic literature searches (to July 2019).<h4>Study selection</h4>Prospective cohort studies of community-dwelling men with total testosterone measured using mass spectrometry.<h4>Data extraction</h4>Individual participant data (IPD) (9 studies; <i>n</i> = 21 074) and aggregate data (2 studies; <i>n</i> = 4075). Sociodemographic, lifestyle, and health factors and concentrations of total testosterone, sex hormone-binding globulin (SHBG), luteinizing hormone (LH), dihydrotestosterone, and estradiol were extracted.<h4>Data synthesis</h4>Two-stage raAnnals of internal medicineFactors Associated With Circulating Sex Hormones in Men : Individual Participant Data Meta-analyses.PMC10995451NNF18OC0034464NNF16OC0021228R01 AG066671NNF14OC0010513NNF18OC0033898MC_UU_00004/06NNF13OC0005785UL1 TR002369NNF19OC0055250NNF22OC0078421Mellstrom DVanderschueren DKarlsson MBallantyne CMTravison TGOhlsson CYeap BBHannemann ABhasin SWittert GASteveling AHandelsman DJMurray KHsu BAdams RJFlicker LOrwoll ESAntonio LHankey GJMatsumoto AMBauer DCMartin SAQuartagno MBiggs MLWu FCWHaring RShores MMO'Neill TWMarriott RJCouper DJTivesten ACawthon PMDobs ASfalseFactors Associated With Circulating Sex Hormones in Men : Individual Participant Data Meta-analyses.<h4>Background</h4>Various factors modulate circulating testosterone in men, affecting interpretation of testosterone measurements.<h4>Purpose</h4>To clarify factors associated with variations in sex hormone concentrations.<h4>Data sources</h4>Systematic literature searches (to July 2019).<h4>Study selection</h4>Prospective cohort studies of community-dwelling men with total testosterone measured using mass spectrometry.<h4>Data extraction</h4>Individual participant data (IPD) (9 studies; <i>n</i> = 21 074) and aggregate data (2 studies; <i>n</i> = 4075). Sociodemographic, lifestyle, and health factors and concentrations of total testosterone, sex hormone-binding globulin (SHBG), luteinizing hormone (LH), dihydrotestosterone, and estradiol were extracted.<h4>Data synthesis</h4>Two-stage ra2023-01-01T00:00:00Z2023 Sep2026-06-03T17:05:03.007Z2026-05-30T03:06:03.275ZS-EPMC109954513763972010.7326/M23-0342