{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15"],"submitter":["Martinez-Gomez LE"],"funding":["Consejo Nacional de Ciencia y Tecnología"],"pubmed_abstract":["<h4>Introduction</h4>Serine proteases play a critical role during SARS-CoV-2 infection. Therefore, polymorphisms of transmembrane protease serine 2 (<i>TMPRSS2</i>) and serpine family E member 1 (<i>SERPINE1</i>) could help to elucidate the contribution of variability to COVID-19 outcomes.<h4>Methods</h4>To evaluate the genetic variants of the genes previously associated with COVID-19 outcomes, we performed a cross-sectional study in which 1536 SARS-CoV-2-positive participants were enrolled. <i>TMPRSS2</i> (rs2070788, rs75603675, rs12329760) and <i>SERPINE1</i> (rs2227631, rs2227667, rs2070682, rs2227692) were genotyped using the Open Array Platform. The association of polymorphisms with disease outcomes was determined by logistic regression analysis adjusted for covariates (age, sex, hype"],"journal":["Frontiers in immunology"],"pagination":["1335963"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11004237"],"repository":["biostudies-literature"],"pubmed_title":["The fatal contribution of serine protease-related genetic variants to COVID-19 outcomes."],"pmcid":["PMC11004237"],"pubmed_authors":["Martinez-Cuazitl A","Rodriguez-Perez JM","Martinez-Ruiz FJ","Olea-Torres J","Vargas-Alarcon G","Suarez-Ahedo C","Pineda C","Posadas-Sanchez R","Martinez-Armenta C","Vazquez-Cardenas P","Gomez-Martin D","Segura-Kato Y","de la Pena A","Vazquez-Zapien GJ","Vidal-Vazquez RP","Ramos-Tavera L","Martinez-Gomez LE","Zayago-Angeles DM","Tusie-Luna T","Camacho-Rea MDC","Mata-Miranda MM","Herrera-Lopez B","Ordonez-Sanchez ML","Martinez-Nava GA","Fragoso JM","Ramirez-Hinojosa JP","Lopez-Reyes A","Mendez-Aguilera A"],"additional_accession":[]},"is_claimable":false,"name":"The fatal contribution of serine protease-related genetic variants to COVID-19 outcomes.","description":"<h4>Introduction</h4>Serine proteases play a critical role during SARS-CoV-2 infection. Therefore, polymorphisms of transmembrane protease serine 2 (<i>TMPRSS2</i>) and serpine family E member 1 (<i>SERPINE1</i>) could help to elucidate the contribution of variability to COVID-19 outcomes.<h4>Methods</h4>To evaluate the genetic variants of the genes previously associated with COVID-19 outcomes, we performed a cross-sectional study in which 1536 SARS-CoV-2-positive participants were enrolled. <i>TMPRSS2</i> (rs2070788, rs75603675, rs12329760) and <i>SERPINE1</i> (rs2227631, rs2227667, rs2070682, rs2227692) were genotyped using the Open Array Platform. The association of polymorphisms with disease outcomes was determined by logistic regression analysis adjusted for covariates (age, sex, hype","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2026-05-29T12:40:02.034Z","creation":"2024-11-19T19:41:53.128Z"},"accession":"S-EPMC11004237","cross_references":{"pubmed":["38601158"],"doi":["10.3389/fimmu.2024.1335963"]}}