biostudies-literatureUnknown15Martinez-Gomez LEConsejo Nacional de Ciencia y Tecnología<h4>Introduction</h4>Serine proteases play a critical role during SARS-CoV-2 infection. Therefore, polymorphisms of transmembrane protease serine 2 (<i>TMPRSS2</i>) and serpine family E member 1 (<i>SERPINE1</i>) could help to elucidate the contribution of variability to COVID-19 outcomes.<h4>Methods</h4>To evaluate the genetic variants of the genes previously associated with COVID-19 outcomes, we performed a cross-sectional study in which 1536 SARS-CoV-2-positive participants were enrolled. <i>TMPRSS2</i> (rs2070788, rs75603675, rs12329760) and <i>SERPINE1</i> (rs2227631, rs2227667, rs2070682, rs2227692) were genotyped using the Open Array Platform. The association of polymorphisms with disease outcomes was determined by logistic regression analysis adjusted for covariates (age, sex, hypeFrontiers in immunology1335963https://www.ebi.ac.uk/biostudies/studies/S-EPMC11004237biostudies-literatureThe fatal contribution of serine protease-related genetic variants to COVID-19 outcomes.PMC11004237Martinez-Cuazitl ARodriguez-Perez JMMartinez-Ruiz FJOlea-Torres JVargas-Alarcon GSuarez-Ahedo CPineda CPosadas-Sanchez RMartinez-Armenta CVazquez-Cardenas PGomez-Martin DSegura-Kato Yde la Pena AVazquez-Zapien GJVidal-Vazquez RPRamos-Tavera LMartinez-Gomez LEZayago-Angeles DMTusie-Luna TCamacho-Rea MDCMata-Miranda MMHerrera-Lopez BOrdonez-Sanchez MLMartinez-Nava GAFragoso JMRamirez-Hinojosa JPLopez-Reyes AMendez-Aguilera AfalseThe fatal contribution of serine protease-related genetic variants to COVID-19 outcomes.<h4>Introduction</h4>Serine proteases play a critical role during SARS-CoV-2 infection. Therefore, polymorphisms of transmembrane protease serine 2 (<i>TMPRSS2</i>) and serpine family E member 1 (<i>SERPINE1</i>) could help to elucidate the contribution of variability to COVID-19 outcomes.<h4>Methods</h4>To evaluate the genetic variants of the genes previously associated with COVID-19 outcomes, we performed a cross-sectional study in which 1536 SARS-CoV-2-positive participants were enrolled. <i>TMPRSS2</i> (rs2070788, rs75603675, rs12329760) and <i>SERPINE1</i> (rs2227631, rs2227667, rs2070682, rs2227692) were genotyped using the Open Array Platform. The association of polymorphisms with disease outcomes was determined by logistic regression analysis adjusted for covariates (age, sex, hype2024-01-01T00:00:00Z20242026-05-29T12:40:02.034Z2024-11-19T19:41:53.128ZS-EPMC110042373860115810.3389/fimmu.2024.1335963