{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Pees B"],"funding":["Deutsche Forschungsgemeinschaft","NIH HHS"],"pagination":["e0346323"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11005407"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(4)"],"pubmed_abstract":["The <i>Caenorhabditis elegans</i> natural microbiota isolates <i>Pseudomonas lurida</i> MYb11 and <i>Pseudomonas fluorescens</i> MYb115 protect the host against pathogens through distinct mechanisms. While <i>P. lurida</i> produces an antimicrobial compound and directly inhibits pathogen growth, <i>P. fluorescens</i> MYb115 protects the host without affecting pathogen growth. It is unknown how these two protective microbes affect host biological processes. We used a proteomics approach to elucidate the <i>C. elegans</i> response to MYb11 and MYb115. We found that both <i>Pseudomonas</i> isolates increase vitellogenin protein production in young adults, which confirms previous findings on the effect of microbiota on <i>C. elegans</i> reproductive timing. Moreover, the <i>C. elegans</i> resp"],"journal":["mBio"],"pubmed_title":["The <i>Caenorhabditis elegans</i> proteome response to two protective <i>Pseudomonas</i> symbionts."],"pmcid":["PMC11005407"],"funding_grant_id":["P40 OD010440","CRC1182 Project A1.2, CRC1182 Project Z3"],"pubmed_authors":["Tholey A","Hamerich IK","Dierking K","Pees B","Peters L","Treitz C","Kissoyan KAB"],"additional_accession":[]},"is_claimable":false,"name":"The <i>Caenorhabditis elegans</i> proteome response to two protective <i>Pseudomonas</i> symbionts.","description":"The <i>Caenorhabditis elegans</i> natural microbiota isolates <i>Pseudomonas lurida</i> MYb11 and <i>Pseudomonas fluorescens</i> MYb115 protect the host against pathogens through distinct mechanisms. While <i>P. lurida</i> produces an antimicrobial compound and directly inhibits pathogen growth, <i>P. fluorescens</i> MYb115 protects the host without affecting pathogen growth. It is unknown how these two protective microbes affect host biological processes. We used a proteomics approach to elucidate the <i>C. elegans</i> response to MYb11 and MYb115. We found that both <i>Pseudomonas</i> isolates increase vitellogenin protein production in young adults, which confirms previous findings on the effect of microbiota on <i>C. elegans</i> reproductive timing. Moreover, the <i>C. elegans</i> resp","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Apr","modification":"2026-05-29T12:39:48.196Z","creation":"2024-11-19T19:41:43.747Z"},"accession":"S-EPMC11005407","cross_references":{"pubmed":["38411078"],"doi":["10.1128/mbio.03463-23"]}}