{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Smith C"],"funding":["NCATS NIH HHS","NCRR NIH HHS","NHLBI NIH HHS","NIGMS NIH HHS"],"pagination":["e032493"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11010028"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(6)"],"pubmed_abstract":["<h4>Background</h4>Among individuals with hypertension and low diastolic blood pressure (DBP), the optimal BP target remains controversial due to concerns that BP lowering may reduce coronary perfusion. We determined the impact of intensive BP control among individuals with elevated systolic BP who have low DBP and elevated hs-cTnT (high-sensitivity cardiac troponin T) levels.<h4>Methods and results</h4>A total of 8828 participants in SPRINT (Systolic Blood Pressure Intervention Trial) were stratified by baseline DBP. Those with low DBP (<70 mm Hg) were further stratified by elevated hs-cTnT (≥14 ng/L) at baseline. The effects of intensive versus standard BP lowering on a cardiovascular disease composite end point, all-cause death, and 1-year change in hs-cTnT were determined. The combinat"],"journal":["Journal of the American Heart Association"],"pubmed_title":["Intensive Blood Pressure Lowering in Individuals With Low Diastolic Blood Pressure and Elevated Troponin Levels in SPRINT."],"pmcid":["PMC11010028"],"funding_grant_id":["UL1 TR000075","UL1 TR000073","UL1 TR001064","KL2 TR001859","UL1 TR001420","HHSN268200900049C","UL1 TR000433","UL1 TR000439","HHSN268200900047C","R01 HL144112","UL1 RR024134","UL1 TR000064","UL1 TR000002","UL1 TR000003","HHSN268200900048C","UL1 TR000105","UL1 TR000445","UL1 TR000005","P30 GM103337","HHSN268200900040C","UL1 RR025755","HHSN268200900046C","UL1 RR025752","UL1 RR025771","UL1 TR000093","UL1 TR000050"],"pubmed_authors":["Killeen AA","Ascher SB","Scherzer R","Kravitz RL","Shlipak MG","de Lemos JA","Ix JH","Smith C","Ballantyne CM","Berry JD","Nambi V"],"additional_accession":[]},"is_claimable":false,"name":"Intensive Blood Pressure Lowering in Individuals With Low Diastolic Blood Pressure and Elevated Troponin Levels in SPRINT.","description":"<h4>Background</h4>Among individuals with hypertension and low diastolic blood pressure (DBP), the optimal BP target remains controversial due to concerns that BP lowering may reduce coronary perfusion. We determined the impact of intensive BP control among individuals with elevated systolic BP who have low DBP and elevated hs-cTnT (high-sensitivity cardiac troponin T) levels.<h4>Methods and results</h4>A total of 8828 participants in SPRINT (Systolic Blood Pressure Intervention Trial) were stratified by baseline DBP. Those with low DBP (<70 mm Hg) were further stratified by elevated hs-cTnT (≥14 ng/L) at baseline. The effects of intensive versus standard BP lowering on a cardiovascular disease composite end point, all-cause death, and 1-year change in hs-cTnT were determined. The combinat","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2025-04-19T20:25:23.381Z","creation":"2025-04-19T20:25:23.381Z"},"accession":"S-EPMC11010028","cross_references":{"pubmed":["38497469"],"doi":["10.1161/JAHA.123.032493"]}}