biostudies-literatureLazzerini PEBLRD VANHLBI NIH HHSe032071https://www.ebi.ac.uk/biostudies/studies/S-EPMC11010073biostudies-literatureUnknown13(4)<h4>Background</h4>Although accumulating data indicate that IL-6 (interleukin-6) can promote heart rate-corrected QT interval (QTc) prolongation via direct and indirect effects on cardiac electrophysiology, current evidence comes from basic investigations and small clinical studies only. Therefore, IL-6 is still largely ignored in the clinical management of long-QT syndrome and related arrhythmias. The aim of this study was to estimate the risk of QTc prolongation associated with elevated IL-6 levels in a large population of unselected subjects.<h4>Methods and results</h4>An observational study using the Veterans Affairs Informatics and Computing Infrastructure was performed. Participants were US veterans who had an ECG and were tested for IL-6. Descriptive statistics and univariate and muJournal of the American Heart AssociationElevated Interleukin-6 Levels Are Associated With an Increased Risk of QTc Interval Prolongation in a Large Cohort of US Veterans.PMC11010073I01 BX002137R01 HL164415Acampa MSalvadori FCupelli MCevenini GMarzotti TBisogno SAccioli RCartocci ACapecchi PLEl-Sherif NBoutjdir MSalvini VBernardini SLazzerini PEBicchi MLaghi-Pasini FBertolozzi IVerrengia DDonati GfalseElevated Interleukin-6 Levels Are Associated With an Increased Risk of QTc Interval Prolongation in a Large Cohort of US Veterans.<h4>Background</h4>Although accumulating data indicate that IL-6 (interleukin-6) can promote heart rate-corrected QT interval (QTc) prolongation via direct and indirect effects on cardiac electrophysiology, current evidence comes from basic investigations and small clinical studies only. Therefore, IL-6 is still largely ignored in the clinical management of long-QT syndrome and related arrhythmias. The aim of this study was to estimate the risk of QTc prolongation associated with elevated IL-6 levels in a large population of unselected subjects.<h4>Methods and results</h4>An observational study using the Veterans Affairs Informatics and Computing Infrastructure was performed. Participants were US veterans who had an ECG and were tested for IL-6. Descriptive statistics and univariate and mu2024-01-01T00:00:00Z2024 Feb2025-04-26T20:11:11.894Z2025-04-06T16:19:49.213ZS-EPMC110100733834878910.1161/JAHA.123.032071