{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Shakt G"],"funding":["BLRD VA","NIDDK NIH HHS","Medical Research Council","NHLBI NIH HHS","NIAAA NIH HHS","CSRD VA"],"pagination":["e030233"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11010076"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(4)"],"pubmed_abstract":["<h4>Background</h4>Major depressive disorder (MDD) has been identified as a causal risk factor for multiple forms of cardiovascular disease. Although observational evidence has linked MDD to peripheral artery disease (PAD), causal evidence of this relationship is lacking.<h4>Methods and results</h4>Inverse variance weighted 2-sample Mendelian randomization was used to test the association the between genetic liability for MDD and genetic liability for PAD. Genetic liability for MDD was associated with increased genetic liability for PAD (odds ratio [OR], 1.17 [95% CI, 1.06-1.29]; <i>P</i>=2.6×10<sup>-3</sup>). Genetic liability for MDD was also associated with increased genetically determined lifetime smoking (<i>β</i>=0.11 [95% CI, 0.078-0.14]; <i>P</i>=1.2×10<sup>-12</sup>), decreased al"],"journal":["Journal of the American Heart Association"],"pubmed_title":["Major Depressive Disorder Impacts Peripheral Artery Disease Risk Through Intermediary Risk Factors."],"pmcid":["PMC11010076"],"funding_grant_id":["T32 HL007843","IK2 CX001780","K01 AA028292","R01 HL122939","UM1 DK126194","IK2 BX005759","MC_UU_00032/3","R01 HL101388"],"pubmed_authors":["Scali ST","Tsao NL","Tsao P","Damrauer SM","Kember RL","Shakt G","Levin MG","Klarin D","Walker V","Voight BF"],"additional_accession":[]},"is_claimable":false,"name":"Major Depressive Disorder Impacts Peripheral Artery Disease Risk Through Intermediary Risk Factors.","description":"<h4>Background</h4>Major depressive disorder (MDD) has been identified as a causal risk factor for multiple forms of cardiovascular disease. Although observational evidence has linked MDD to peripheral artery disease (PAD), causal evidence of this relationship is lacking.<h4>Methods and results</h4>Inverse variance weighted 2-sample Mendelian randomization was used to test the association the between genetic liability for MDD and genetic liability for PAD. Genetic liability for MDD was associated with increased genetic liability for PAD (odds ratio [OR], 1.17 [95% CI, 1.06-1.29]; <i>P</i>=2.6×10<sup>-3</sup>). Genetic liability for MDD was also associated with increased genetically determined lifetime smoking (<i>β</i>=0.11 [95% CI, 0.078-0.14]; <i>P</i>=1.2×10<sup>-12</sup>), decreased al","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Feb","modification":"2025-04-04T09:34:22.506Z","creation":"2025-04-04T09:34:22.506Z"},"accession":"S-EPMC11010076","cross_references":{"pubmed":["38362853"],"doi":["10.1161/JAHA.123.030233"]}}