biostudies-literatureUnknown13(4)Santoro F<h4>Background</h4>Neurological disorders as a risk factor for Takotsubo syndrome (TTS) are not well characterized. The aim of the study was to evaluate TTS-associated neurological phenotypes and outcome.<h4>Methods and results</h4>Patients with TTS enrolled in the international multicenter GEIST (German Italian Spanish Takotsubo) registry were analyzed. Prevalence, clinical characteristics, and short- and long-term outcomes of patients with TTS were recorded. A subgroup analysis of the 5 most represented neurological disorders was performed. In total, 400 (17%) of 2301 patients had neurological disorders. The most represented neurological conditions were previous cerebrovascular events (39%), followed by neurodegenerative disorders (30.7%), migraine (10%), epilepsy (9.5%), and brain tumorJournal of the American Heart Associatione032128https://www.ebi.ac.uk/biostudies/studies/S-EPMC11010100biostudies-literatureNeurological Disorders in Takotsubo Syndrome: Clinical Phenotypes and Outcomes.PMC11010100Stiermaier TBrunetti NDThiele HEitel IMontisci RBartolomucci FVitale EGuerra FAkin IMariano EBlanco EEl-Battrawy ICaldarola PVedia OSalamanca JNovo GPerez-Castellanos ASantoro FCetera RMartin APais JLMartino TRagnatela IMusumeci BNunez Gil IJCacciotti LArcari LfalseNeurological Disorders in Takotsubo Syndrome: Clinical Phenotypes and Outcomes.<h4>Background</h4>Neurological disorders as a risk factor for Takotsubo syndrome (TTS) are not well characterized. The aim of the study was to evaluate TTS-associated neurological phenotypes and outcome.<h4>Methods and results</h4>Patients with TTS enrolled in the international multicenter GEIST (German Italian Spanish Takotsubo) registry were analyzed. Prevalence, clinical characteristics, and short- and long-term outcomes of patients with TTS were recorded. A subgroup analysis of the 5 most represented neurological disorders was performed. In total, 400 (17%) of 2301 patients had neurological disorders. The most represented neurological conditions were previous cerebrovascular events (39%), followed by neurodegenerative disorders (30.7%), migraine (10%), epilepsy (9.5%), and brain tumor2024-01-01T00:00:00Z2024 Feb2025-04-06T23:15:03.975Z2025-04-06T23:15:03.975ZS-EPMC110101003835323810.1161/JAHA.123.032128