biostudies-literatureJiang SYunnan Revitalization Talent Support Program "Young Talent" ProjectYunnan Province Science and Technology DepartmentNational Natural Science Foundation of China1581https://www.ebi.ac.uk/biostudies/studies/S-EPMC11013477biostudies-literatureUnknown29(7)A novel <i>Lycopodium</i> alkaloid, lycocasine A (<b>1</b>), and seven known <i>Lycopodium</i> alkaloids (<b>2</b>-<b>8</b>), were isolated from <i>Lycopodiastrum casuarinoides</i>. Their structures were determined through NMR, HRESIMS, and X-ray diffraction analysis. Compound <b>1</b> features an unprecedented 5/6/6 tricyclic skeleton, highlighted by a 5-aza-tricyclic[6,3,1,0^2,6]dodecane motif. In bioactivity assays, compound <b>1</b> demonstrated weak inhibitory activity against acid-sensing ion channel 1a.Molecules (Basel, Switzerland)Lycocasine A, a <i>Lycopodium</i> Alkaloid from <i>Lycopodiastrum casuarinoides</i> and Its Acid-Sensing Ion Channel 1a Inhibitory Activity.PMC11013477NO21837003202305AH340005Zhao QSJiang SLi WYGao BBfalseLycocasine A, a <i>Lycopodium</i> Alkaloid from <i>Lycopodiastrum casuarinoides</i> and Its Acid-Sensing Ion Channel 1a Inhibitory Activity.A novel <i>Lycopodium</i> alkaloid, lycocasine A (<b>1</b>), and seven known <i>Lycopodium</i> alkaloids (<b>2</b>-<b>8</b>), were isolated from <i>Lycopodiastrum casuarinoides</i>. Their structures were determined through NMR, HRESIMS, and X-ray diffraction analysis. Compound <b>1</b> features an unprecedented 5/6/6 tricyclic skeleton, highlighted by a 5-aza-tricyclic[6,3,1,0^2,6]dodecane motif. In bioactivity assays, compound <b>1</b> demonstrated weak inhibitory activity against acid-sensing ion channel 1a.2024-01-01T00:00:00Z2024 Apr2024-11-12T11:16:55.555Z2024-11-12T11:16:55.555ZS-EPMC110134773861185910.3390/molecules29071581