biostudies-literatureRicherson WTNCATS NIH HHSNational Institute of Diabetes and Digestive and Kidney DiseasesNIDDK NIH HHSNational Institutes of HealthNIH HHS178-187https://www.ebi.ac.uk/biostudies/studies/S-EPMC11014772biostudies-literatureUnknown28(2)<h4>Introduction</h4>Hemodialysis patients have increased white matter and gray matter pathology in the brain relative to controls based on MRI. Diffusion tensor imaging is useful in detecting differences between hemodialysis and controls but has not identified the expected longitudinal decline in hemodialysis patients. In this study we implemented specialized post-processing techniques to reduce noise to detect longitudinal changes in diffusion tensor imaging parameters and evaluated for any association with changes in cognition.<h4>Methods</h4>We collected anatomical and diffusion MRIs as well as cognitive testing from in-center hemodialysis patients at baseline and 1 year later. Gray matter thickness, white matter volume, and white matter diffusion tensor imaging parameters were measureHemodialysis international. International Symposium on Home HemodialysisLongitudinal changes in diffusion tensor imaging in hemodialysis patients.PMC11014772K23 DK113119NCATS TL‐1TR001437NCATS TL-1TR001437TL1 TR001437Wolfgram DFRicherson WTSchmit BDfalseLongitudinal changes in diffusion tensor imaging in hemodialysis patients.<h4>Introduction</h4>Hemodialysis patients have increased white matter and gray matter pathology in the brain relative to controls based on MRI. Diffusion tensor imaging is useful in detecting differences between hemodialysis and controls but has not identified the expected longitudinal decline in hemodialysis patients. In this study we implemented specialized post-processing techniques to reduce noise to detect longitudinal changes in diffusion tensor imaging parameters and evaluated for any association with changes in cognition.<h4>Methods</h4>We collected anatomical and diffusion MRIs as well as cognitive testing from in-center hemodialysis patients at baseline and 1 year later. Gray matter thickness, white matter volume, and white matter diffusion tensor imaging parameters were measure2024-01-01T00:00:00Z2024 Apr2025-06-25T03:04:27.562Z2025-06-25T03:04:27.562ZS-EPMC110147723835136510.1111/hdi.13133