biostudies-literatureLiu QNCI NIH HHS1295-1303https://www.ebi.ac.uk/biostudies/studies/S-EPMC11015033biostudies-literatureUnknown130(8)<h4>Background</h4>Previous studies have observed inconsistent associations between birth weight and aggressive prostate cancer risk. This study aimed to prospectively analyse this association in the Health Professionals Follow-up Study (HPFS).<h4>Methods</h4>Birth weight was self-reported in 1994, and prostate cancer diagnoses were assessed biennially through January 2017 and confirmed by medical record review. Multivariable Cox proportional hazards regression was used to evaluate the association between birth weight and prostate cancer risk and mortality.<h4>Results</h4>Among 19,889 eligible men, 2520 were diagnosed with prostate cancer, including 643 with higher-grade/advanced stage, 296 with lethal, and 248 with fatal disease. Overall, no association was observed for increasing birth wBritish journal of cancerA prospective study of birth weight and prostate cancer risk and mortality in the Health Professionals Follow-up Study.PMC11015033P30 CA091842P50 CA058236Giovannucci ELMucci LASutcliffe SZhang YLiu QVaselkiv JBPlatz EAfalseA prospective study of birth weight and prostate cancer risk and mortality in the Health Professionals Follow-up Study.<h4>Background</h4>Previous studies have observed inconsistent associations between birth weight and aggressive prostate cancer risk. This study aimed to prospectively analyse this association in the Health Professionals Follow-up Study (HPFS).<h4>Methods</h4>Birth weight was self-reported in 1994, and prostate cancer diagnoses were assessed biennially through January 2017 and confirmed by medical record review. Multivariable Cox proportional hazards regression was used to evaluate the association between birth weight and prostate cancer risk and mortality.<h4>Results</h4>Among 19,889 eligible men, 2520 were diagnosed with prostate cancer, including 643 with higher-grade/advanced stage, 296 with lethal, and 248 with fatal disease. Overall, no association was observed for increasing birth w2024-01-01T00:00:00Z2024 May2025-04-04T02:04:23.849Z2025-04-04T02:04:23.849ZS-EPMC110150333838885710.1038/s41416-024-02593-y