biostudies-literatureUnknown10(7)Li Q<h4>Background</h4>ARF family proteins are a kind of small GTPases, which are involved in regulating a variety of basic functions of cells. In recent years, the role and molecular regulatory mechanisms of ARFs in tumor progression have received increasing attention, and research reports on most of their family members are increasing. However, research on the clinical and pathological relevance of ARF5 in cancer, especially in hepatocellular carcinoma, still needs to be improved.<h4>Methods</h4>RNA-seq data in the Cancer Genome Atlas (TCGA) and genome tissue expression (GTEx) databases were used to analyze the expression and pathological data of ARFs family in Pan-cancer. Kaplan-Meier and Cox regression were used for prognostic analysis of ARF5 and Pan-cancer. Combined with ImmuCellAI databHeliyone29099https://www.ebi.ac.uk/biostudies/studies/S-EPMC11015141biostudies-literaturePan-cancer analysis of ARFs family and ARF5 promoted the progression of hepatocellular carcinoma.PMC11015141Ma PJing XWen HLu NLi FZhang HLi QZhang MWang XSong XYao WfalsePan-cancer analysis of ARFs family and ARF5 promoted the progression of hepatocellular carcinoma.<h4>Background</h4>ARF family proteins are a kind of small GTPases, which are involved in regulating a variety of basic functions of cells. In recent years, the role and molecular regulatory mechanisms of ARFs in tumor progression have received increasing attention, and research reports on most of their family members are increasing. However, research on the clinical and pathological relevance of ARF5 in cancer, especially in hepatocellular carcinoma, still needs to be improved.<h4>Methods</h4>RNA-seq data in the Cancer Genome Atlas (TCGA) and genome tissue expression (GTEx) databases were used to analyze the expression and pathological data of ARFs family in Pan-cancer. Kaplan-Meier and Cox regression were used for prognostic analysis of ARF5 and Pan-cancer. Combined with ImmuCellAI datab2024-01-01T00:00:00Z2024 Apr2025-04-04T09:33:00.655Z2025-04-04T09:33:00.655ZS-EPMC110151413861793210.1016/j.heliyon.2024.e29099