biostudies-literatureUnknown28(2)Taghaddos D<h4>Background</h4>Prurigo nodularis (PN) is a complex chronic skin disease characterized by severe pruritic nodules. PN is often associated with mental health disorders and chronic medical comorbidities. Until recently, PN treatment has been challenging and difficult.<h4>Objectives</h4>This study aims to describe the demographic, clinical characteristics, and comorbidities associated with PN. Also, we aim to describe the effectiveness of systemic therapies, including methotrexate, cyclosporine, and narrow band ultraviolet (NB-UVB) in adult patients with PN.<h4>Methods</h4>This is a retrospective chart review of adult patients diagnosed with PN at Hamilton Health Science Center and/or McMaster University in Hamilton, Ontario, between 2015 and 2023.<h4>Results</h4>The study included 81 patiJournal of cutaneous medicine and surgery141-145https://www.ebi.ac.uk/biostudies/studies/S-EPMC11015701biostudies-literatureClinical Characteristics and Treatment Outcomes of Prurigo Nodularis: A Retrospective Study.PMC11015701Savinova ITaghaddos DAbu-Hilal MfalseClinical Characteristics and Treatment Outcomes of Prurigo Nodularis: A Retrospective Study.<h4>Background</h4>Prurigo nodularis (PN) is a complex chronic skin disease characterized by severe pruritic nodules. PN is often associated with mental health disorders and chronic medical comorbidities. Until recently, PN treatment has been challenging and difficult.<h4>Objectives</h4>This study aims to describe the demographic, clinical characteristics, and comorbidities associated with PN. Also, we aim to describe the effectiveness of systemic therapies, including methotrexate, cyclosporine, and narrow band ultraviolet (NB-UVB) in adult patients with PN.<h4>Methods</h4>This is a retrospective chart review of adult patients diagnosed with PN at Hamilton Health Science Center and/or McMaster University in Hamilton, Ontario, between 2015 and 2023.<h4>Results</h4>The study included 81 pati2024-01-01T00:00:00Z2024 Mar-Apr2025-04-04T09:34:00.707Z2025-04-04T09:34:00.707ZS-EPMC110157013828109210.1177/12034754241227808