{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Xie L"],"funding":["National Key R/D Program of China","Natural Science Foundation of Shanghai","National Natural Science Foundation of China","Shanghai Commission of Sciences and Technologies"],"pagination":["206-224"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11016487"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["30(2)"],"pubmed_abstract":["<h4>Background/aims</h4>Cholestatic liver diseases including primary biliary cholangitis (PBC) are associated with active hepatic fibrogenesis, which ultimately progresses to cirrhosis. Activated hepatic stellate cells (HSCs) are the main fibrogenic effectors in response to cholangiocyte damage. JCAD regulates cell proliferation and malignant transformation in nonalcoholic steatoheaptitis-associated hepatocellular carcinoma (NASH-HCC). However, its participation in cholestatic fibrosis has not been explored yet.<h4>Methods</h4>Serial sections of liver tissue of PBC patients were stained with immunofluorescence. Hepatic fibrosis was induced by bile duct ligation (BDL) in wild-type (WT), global JCAD knockout mice (JCAD-KO) and HSC-specific JCAD knockout mice (HSC-JCAD-KO), and evaluated by h"],"journal":["Clinical and molecular hepatology"],"pubmed_title":["JCAD deficiency attenuates activation of hepatic stellate cells and cholestatic fibrosis."],"pmcid":["PMC11016487"],"funding_grant_id":["2016YFE0107400","16140903700","21ZR1450300","82370625","82170624","81871997","81572356"],"pubmed_authors":["Wu J","Yan YJ","Xie L","Ma Y","Chen H","Zhang L","Zhou Y","Ding J","Liu XP","Yang YY","Wang YL","Liu C","Teng X","Yang Q"],"additional_accession":[]},"is_claimable":false,"name":"JCAD deficiency attenuates activation of hepatic stellate cells and cholestatic fibrosis.","description":"<h4>Background/aims</h4>Cholestatic liver diseases including primary biliary cholangitis (PBC) are associated with active hepatic fibrogenesis, which ultimately progresses to cirrhosis. Activated hepatic stellate cells (HSCs) are the main fibrogenic effectors in response to cholangiocyte damage. JCAD regulates cell proliferation and malignant transformation in nonalcoholic steatoheaptitis-associated hepatocellular carcinoma (NASH-HCC). However, its participation in cholestatic fibrosis has not been explored yet.<h4>Methods</h4>Serial sections of liver tissue of PBC patients were stained with immunofluorescence. Hepatic fibrosis was induced by bile duct ligation (BDL) in wild-type (WT), global JCAD knockout mice (JCAD-KO) and HSC-specific JCAD knockout mice (HSC-JCAD-KO), and evaluated by h","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Apr","modification":"2025-04-26T20:08:01.859Z","creation":"2025-04-06T16:20:13.726Z"},"accession":"S-EPMC11016487","cross_references":{"pubmed":["38190829"],"doi":["10.3350/cmh.2023.0506"]}}