{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Melgarejo JD"],"funding":["NIA NIH HHS","National Institutes of Health","NIH HHS","National Institute on Aging"],"pagination":["323-333"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11016833"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["37(5)"],"pubmed_abstract":["Background
Evidence shows that high 24-h blood pressure (BP) variability increases cardiovascular risk. We investigated whether 24-h BP variability relates to mortality and cardiovascular risk due to inherent variability and/or hypertensive loads in 24-h BP.Methods
A total of 1,050 participants from the Maracaibo Aging Study (mean age, 66 years; women, 67.2%) underwent 24-h ambulatory BP monitoring and were followed between 2001 and 2016. To evaluate inherent BP variability, we used average real variability (ARV) as it captures variability among consecutive BP readings. 24-h systolic BP load was the proportion (%) of systolic BP readings ≥130 mm Hg during the daytime and ≥110 during the nighttime. Our primary endpoint was total mortality and major adverse cardiovascular end"],"journal":["American journal of hypertension"],"pubmed_title":["Association of Variability and Hypertensive Loads in 24-h Blood Pressure With Mortality and Cardiovascular Risk."],"pmcid":["PMC11016833"],"funding_grant_id":["P30 AG059305","DP1 AG069870","P30 AG066546","R01 AG036469"],"pubmed_authors":["Mena LJ","Garcia JA","Patil D","Vatcheva KP","Terwilliger JD","Chavez CA","Satizabal CL","Calmon G","Seshadri S","Maestre GE","Melgarejo JD","Silva E","Pirela RV","Lee JH"],"additional_accession":[]},"is_claimable":false,"name":"Association of Variability and Hypertensive Loads in 24-h Blood Pressure With Mortality and Cardiovascular Risk.","description":"Background
Evidence shows that high 24-h blood pressure (BP) variability increases cardiovascular risk. We investigated whether 24-h BP variability relates to mortality and cardiovascular risk due to inherent variability and/or hypertensive loads in 24-h BP.Methods
A total of 1,050 participants from the Maracaibo Aging Study (mean age, 66 years; women, 67.2%) underwent 24-h ambulatory BP monitoring and were followed between 2001 and 2016. To evaluate inherent BP variability, we used average real variability (ARV) as it captures variability among consecutive BP readings. 24-h systolic BP load was the proportion (%) of systolic BP readings ≥130 mm Hg during the daytime and ≥110 during the nighttime. Our primary endpoint was total mortality and major adverse cardiovascular end","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Apr","modification":"2025-04-21T23:56:39.861Z","creation":"2025-04-05T19:19:13.562Z"},"accession":"S-EPMC11016833","cross_references":{"pubmed":["38294177"],"doi":["10.1093/ajh/hpae011"]}}