biostudies-literatureMelgarejo JDNIA NIH HHSNational Institutes of HealthNIH HHSNational Institute on Aging323-333https://www.ebi.ac.uk/biostudies/studies/S-EPMC11016833biostudies-literatureUnknown37(5)<h4>Background</h4>Evidence shows that high 24-h blood pressure (BP) variability increases cardiovascular risk. We investigated whether 24-h BP variability relates to mortality and cardiovascular risk due to inherent variability and/or hypertensive loads in 24-h BP.<h4>Methods</h4>A total of 1,050 participants from the Maracaibo Aging Study (mean age, 66 years; women, 67.2%) underwent 24-h ambulatory BP monitoring and were followed between 2001 and 2016. To evaluate inherent BP variability, we used average real variability (ARV) as it captures variability among consecutive BP readings. 24-h systolic BP load was the proportion (%) of systolic BP readings ≥130 mm Hg during the daytime and ≥110 during the nighttime. Our primary endpoint was total mortality and major adverse cardiovascular endAmerican journal of hypertensionAssociation of Variability and Hypertensive Loads in 24-h Blood Pressure With Mortality and Cardiovascular Risk.PMC11016833P30 AG059305DP1 AG069870P30 AG066546R01 AG036469Mena LJGarcia JAPatil DVatcheva KPTerwilliger JDChavez CASatizabal CLCalmon GSeshadri SMaestre GEMelgarejo JDSilva EPirela RVLee JHfalseAssociation of Variability and Hypertensive Loads in 24-h Blood Pressure With Mortality and Cardiovascular Risk.<h4>Background</h4>Evidence shows that high 24-h blood pressure (BP) variability increases cardiovascular risk. We investigated whether 24-h BP variability relates to mortality and cardiovascular risk due to inherent variability and/or hypertensive loads in 24-h BP.<h4>Methods</h4>A total of 1,050 participants from the Maracaibo Aging Study (mean age, 66 years; women, 67.2%) underwent 24-h ambulatory BP monitoring and were followed between 2001 and 2016. To evaluate inherent BP variability, we used average real variability (ARV) as it captures variability among consecutive BP readings. 24-h systolic BP load was the proportion (%) of systolic BP readings ≥130 mm Hg during the daytime and ≥110 during the nighttime. Our primary endpoint was total mortality and major adverse cardiovascular end2024-01-01T00:00:00Z2024 Apr2025-04-21T23:56:39.861Z2025-04-05T19:19:13.562ZS-EPMC110168333829417710.1093/ajh/hpae011