{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["von der Schulenburg P"],"funding":["Marylyn Martina Addo","Julian Schulze zur Wiesch"],"pagination":["339-351"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11017769"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(3)"],"pubmed_abstract":["<h4>Background</h4>In the third year of the SARS-CoV-2 pandemic, little is known about the vaccine- and infection-induced immune response in liver transplant recipients (LTR) and liver cirrhosis patients (LCP).<h4>Objective</h4>This cross-sectional study assessed the vaccination coverage, infection rate, and the resulting humoral and cellular SARS-CoV-2-specific immune responses in a cohort of LTR and LCP at the University Medical Center Hamburg-Eppendorf, Germany between March and May 2023.<h4>Methods</h4>Clinical and laboratory data from 244 consecutive patients (160 LTR and 84 LCP) were collected via chart review and a patient survey. Immune responses were determined via standard spike(S)- and nucleocapsid-protein serology and a spike-specific Interferon-gamma release assay (IGRA).<h4>R"],"journal":["United European gastroenterology journal"],"pubmed_title":["High vaccination coverage and infection rate result in a robust SARS-CoV-2-specific immunity in the majority of liver cirrhosis and transplant patients: A single-center cross-sectional study."],"pmcid":["PMC11017769"],"funding_grant_id":["SFB1328, project A12 and DZIF","DZIFTTU 01709"],"pubmed_authors":["Harberts A","Jahnke-Triankowski J","Jorg V","Wehmeyer M","Pischke S","Herting A","Drolz A","Schulze Zur Wiesch J","von der Schulenburg P","Lutgehetmann M","Lohse AW","Sterneck M","Hubener P","Fischer L","Piecha F","Addo MM"],"additional_accession":[]},"is_claimable":false,"name":"High vaccination coverage and infection rate result in a robust SARS-CoV-2-specific immunity in the majority of liver cirrhosis and transplant patients: A single-center cross-sectional study.","description":"<h4>Background</h4>In the third year of the SARS-CoV-2 pandemic, little is known about the vaccine- and infection-induced immune response in liver transplant recipients (LTR) and liver cirrhosis patients (LCP).<h4>Objective</h4>This cross-sectional study assessed the vaccination coverage, infection rate, and the resulting humoral and cellular SARS-CoV-2-specific immune responses in a cohort of LTR and LCP at the University Medical Center Hamburg-Eppendorf, Germany between March and May 2023.<h4>Methods</h4>Clinical and laboratory data from 244 consecutive patients (160 LTR and 84 LCP) were collected via chart review and a patient survey. Immune responses were determined via standard spike(S)- and nucleocapsid-protein serology and a spike-specific Interferon-gamma release assay (IGRA).<h4>R","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Apr","modification":"2025-04-19T20:27:44.919Z","creation":"2024-11-12T11:15:45.199Z"},"accession":"S-EPMC11017769","cross_references":{"pubmed":["38279837"],"doi":["10.1002/ueg2.12528"]}}