biostudies-literatureFoos GNational Institute of Allergy and Infectious DiseasesNIAID NIH HHSNational Cancer InstituteNCI NIH HHSNational Institutes of Health578-589https://www.ebi.ac.uk/biostudies/studies/S-EPMC11017785biostudies-literatureUnknown84(11)<h4>Background</h4>The Cancer Epitope Database and Analysis Resource (CEDAR) is a newly developed repository of cancer epitope data from peer-reviewed publications, which includes epitope-specific T cell, antibody, and MHC ligand assays. Here we focus on prostate cancer as our first cancer category to demonstrate the capabilities of CEDAR, and to shed light on the advances of epitope-related prostate cancer research.<h4>Results</h4>The meta-analysis focused on a subset of data describing epitopes from 8 prostate-specific (PS) antigens. A total of 460 epitopes were associated with these proteins, 187 T cell, 109B cell, and 271 MHC ligand epitopes. The number of epitopes was not correlated with the length of the protein; however, we found a significant positive correlation between the numberHuman immunologyA meta-analysis of epitopes in prostate-specific antigens identifies opportunities and knowledge gaps.PMC1101778575N93019C00001U24 CA248138U24CA248138Carter HKosaloglu-Yalcin ZPeters BSette AFoos GBlazeska NNielsen MfalseA meta-analysis of epitopes in prostate-specific antigens identifies opportunities and knowledge gaps.<h4>Background</h4>The Cancer Epitope Database and Analysis Resource (CEDAR) is a newly developed repository of cancer epitope data from peer-reviewed publications, which includes epitope-specific T cell, antibody, and MHC ligand assays. Here we focus on prostate cancer as our first cancer category to demonstrate the capabilities of CEDAR, and to shed light on the advances of epitope-related prostate cancer research.<h4>Results</h4>The meta-analysis focused on a subset of data describing epitopes from 8 prostate-specific (PS) antigens. A total of 460 epitopes were associated with these proteins, 187 T cell, 109B cell, and 271 MHC ligand epitopes. The number of epitopes was not correlated with the length of the protein; however, we found a significant positive correlation between the number2023-01-01T00:00:00Z2023 Nov2026-06-02T03:59:47.056Z2025-04-06T23:15:49.075ZS-EPMC110177853767922310.1016/j.humimm.2023.08.145