biostudies-literatureMiller MJNational Institute of Arthritis and Musculoskeletal and Skin DiseasesNIA NIH HHSNIAMS NIH HHSNational Institute on Aginge14097https://www.ebi.ac.uk/biostudies/studies/S-EPMC11019130biostudies-literatureUnknown23(4)The loss of skeletal muscle mass during aging is a significant health concern linked to adverse outcomes in older individuals. Understanding the molecular basis of age-related muscle loss is crucial for developing strategies to combat this debilitating condition. Long noncoding RNAs (lncRNAs) are a largely uncharacterized class of biomolecules that have been implicated in cellular homeostasis and dysfunction across a many tissues and cell types. To identify lncRNAs that might contribute to skeletal muscle aging, we screened for lncRNAs whose expression was altered in vastus lateralis muscle from older compared to young adults. We identified FRAIL1 as an aging-induced lncRNA with high abundance in human skeletal muscle. In healthy young and older adults, skeletal muscle FRAIL1 was increasedAging cellHuman myofiber-enriched aging-induced lncRNA FRAIL1 promotes loss of skeletal muscle function.PMC11019130R01 AG054454NIAMS R01 AR071762NIA R44 AG047684NIAMS R44 AR069400R01 AG060637R44 AG047684NIA R01 AG054454NIA R01 AG060637R44 AR069400Dasari SAdams CMMarcotte GRStrub MDMiller MJKunz HELanza IRArendt BKEbert SMGries KJRyan ZfalseHuman myofiber-enriched aging-induced lncRNA FRAIL1 promotes loss of skeletal muscle function.The loss of skeletal muscle mass during aging is a significant health concern linked to adverse outcomes in older individuals. Understanding the molecular basis of age-related muscle loss is crucial for developing strategies to combat this debilitating condition. Long noncoding RNAs (lncRNAs) are a largely uncharacterized class of biomolecules that have been implicated in cellular homeostasis and dysfunction across a many tissues and cell types. To identify lncRNAs that might contribute to skeletal muscle aging, we screened for lncRNAs whose expression was altered in vastus lateralis muscle from older compared to young adults. We identified FRAIL1 as an aging-induced lncRNA with high abundance in human skeletal muscle. In healthy young and older adults, skeletal muscle FRAIL1 was increased2024-01-01T00:00:00Z2024 Apr2026-05-27T12:18:40.613Z2025-04-06T00:48:01.265ZS-EPMC110191303829780710.1111/acel.14097