{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Boreland AJ"],"funding":["NCATS","NCATS NIH HHS","Rutgers Brain Health Institute","NIAAA NIH HHS","NINDS NIH HHS","Rutgers University","NIGMS NIH HHS","Robert Wood Johnson Foundation","NIGMS","NINDS"],"pagination":["109628"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11019286"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["27(5)"],"pubmed_abstract":["Human immunodeficiency virus type-1 (HIV-1)-associated neurocognitive disorder (HAND) affects up to half of people living with HIV-1 and causes long term neurological consequences. The pathophysiology of HIV-1-induced glial and neuronal functional deficits in humans remains enigmatic. To bridge this gap, we established a model simulating HIV-1 infection in the central nervous system using human induced pluripotent stem cell (iPSC)-derived microglia combined with sliced neocortical organoids. Incubation of microglia with two replication-competent macrophage-tropic HIV-1 strains (JRFL and YU2) elicited productive infection and inflammatory activation. RNA sequencing revealed significant and sustained activation of type I interferon signaling pathways. Incorporating microglia into sliced neoc"],"journal":["iScience"],"pubmed_title":["Sustained type I interferon signaling after human immunodeficiency virus type 1 infection of human iPSC derived microglia and cerebral organoids."],"pmcid":["PMC11019286"],"funding_grant_id":["R01 AA023797","T32 GM135141","R21 NS120806","TL1 TR003019","T32 GM008339"],"pubmed_authors":["Lin HC","Hart RP","Stillitano AC","Abbo Y","Pang ZP","Rabson AB","Boreland AJ","Jiang P"],"additional_accession":[]},"is_claimable":false,"name":"Sustained type I interferon signaling after human immunodeficiency virus type 1 infection of human iPSC derived microglia and cerebral organoids.","description":"Human immunodeficiency virus type-1 (HIV-1)-associated neurocognitive disorder (HAND) affects up to half of people living with HIV-1 and causes long term neurological consequences. The pathophysiology of HIV-1-induced glial and neuronal functional deficits in humans remains enigmatic. To bridge this gap, we established a model simulating HIV-1 infection in the central nervous system using human induced pluripotent stem cell (iPSC)-derived microglia combined with sliced neocortical organoids. Incubation of microglia with two replication-competent macrophage-tropic HIV-1 strains (JRFL and YU2) elicited productive infection and inflammatory activation. RNA sequencing revealed significant and sustained activation of type I interferon signaling pathways. Incorporating microglia into sliced neoc","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 May","modification":"2026-06-01T11:53:19.412Z","creation":"2025-04-22T13:47:25.866Z"},"accession":"S-EPMC11019286","cross_references":{"pubmed":["38628961"],"doi":["10.1016/j.isci.2024.109628"]}}