{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ngoc Mai TT"],"funding":["Vietnam Academy of Science and Technology"],"pagination":["12081-12095"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11019407"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(17)"],"pubmed_abstract":["Twelve compounds were isolated from <i>Mussaenda saigonensis</i> aerial parts through phytochemical analysis and the genus <i>Mussaenda</i> is the first place where the compounds 4-6 and 11-12 have been found. Based on the ability to inhibit NO production in RAW264.7 cells, compound 2 has demonstrated the strongest anti-inflammatory activity <i>in vitro</i> with an IC<sub>50</sub> of 7.6 μM, as opposed to L-NMMA's IC<sub>50</sub> of 41.3 μM. Compound 12 was found to be the most effective inhibitor of alpha-glucosidase enzyme <i>in vitro</i>, with an IC<sub>50</sub> value of 42.4 μM (compared to 168 μM for acarbose). Compounds 1-12 were evaluated <i>in vitro</i> for antimicrobial activity using the paper dish method. Compound 11 demonstrated strong antifungal activity against <i>M. gypseum<"],"journal":["RSC advances"],"pubmed_title":["<i>In vitro</i> and <i>in silico</i> docking and molecular dynamic of antimicrobial activities, alpha-glucosidase, and anti-inflammatory activity of compounds from the aerial parts of <i>Mussaenda saigonensis</i>."],"pmcid":["PMC11019407"],"funding_grant_id":["NCVCC15.02/22-23"],"pubmed_authors":["Minh An TN","Hong Anh NT","Ngoc Mai TT","Tri MD","Minh PN","Nhi Phan NH","Dang VS","Van Hue N","Phat NT","Chi MT","Duong TH"],"additional_accession":[]},"is_claimable":false,"name":"<i>In vitro</i> and <i>in silico</i> docking and molecular dynamic of antimicrobial activities, alpha-glucosidase, and anti-inflammatory activity of compounds from the aerial parts of <i>Mussaenda saigonensis</i>.","description":"Twelve compounds were isolated from <i>Mussaenda saigonensis</i> aerial parts through phytochemical analysis and the genus <i>Mussaenda</i> is the first place where the compounds 4-6 and 11-12 have been found. Based on the ability to inhibit NO production in RAW264.7 cells, compound 2 has demonstrated the strongest anti-inflammatory activity <i>in vitro</i> with an IC<sub>50</sub> of 7.6 μM, as opposed to L-NMMA's IC<sub>50</sub> of 41.3 μM. Compound 12 was found to be the most effective inhibitor of alpha-glucosidase enzyme <i>in vitro</i>, with an IC<sub>50</sub> value of 42.4 μM (compared to 168 μM for acarbose). Compounds 1-12 were evaluated <i>in vitro</i> for antimicrobial activity using the paper dish method. Compound 11 demonstrated strong antifungal activity against <i>M. gypseum<","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Apr","modification":"2026-06-02T10:26:19.496Z","creation":"2025-04-06T00:48:43.06Z"},"accession":"S-EPMC11019407","cross_references":{"pubmed":["38628478"],"doi":["10.1039/d4ra01865f"]}}