biostudies-literatureNgoc Mai TTVietnam Academy of Science and Technology12081-12095https://www.ebi.ac.uk/biostudies/studies/S-EPMC11019407biostudies-literatureUnknown14(17)Twelve compounds were isolated from <i>Mussaenda saigonensis</i> aerial parts through phytochemical analysis and the genus <i>Mussaenda</i> is the first place where the compounds 4-6 and 11-12 have been found. Based on the ability to inhibit NO production in RAW264.7 cells, compound 2 has demonstrated the strongest anti-inflammatory activity <i>in vitro</i> with an IC₅₀ of 7.6 μM, as opposed to L-NMMA's IC₅₀ of 41.3 μM. Compound 12 was found to be the most effective inhibitor of alpha-glucosidase enzyme <i>in vitro</i>, with an IC₅₀ value of 42.4 μM (compared to 168 μM for acarbose). Compounds 1-12 were evaluated <i>in vitro</i> for antimicrobial activity using the paper dish method. Compound 11 demonstrated strong antifungal activity against <i>M. gypseum<RSC advances<i>In vitro</i> and <i>in silico</i> docking and molecular dynamic of antimicrobial activities, alpha-glucosidase, and anti-inflammatory activity of compounds from the aerial parts of <i>Mussaenda saigonensis</i>.PMC11019407NCVCC15.02/22-23Minh An TNHong Anh NTNgoc Mai TTTri MDMinh PNNhi Phan NHDang VSVan Hue NPhat NTChi MTDuong THfalse<i>In vitro</i> and <i>in silico</i> docking and molecular dynamic of antimicrobial activities, alpha-glucosidase, and anti-inflammatory activity of compounds from the aerial parts of <i>Mussaenda saigonensis</i>.Twelve compounds were isolated from <i>Mussaenda saigonensis</i> aerial parts through phytochemical analysis and the genus <i>Mussaenda</i> is the first place where the compounds 4-6 and 11-12 have been found. Based on the ability to inhibit NO production in RAW264.7 cells, compound 2 has demonstrated the strongest anti-inflammatory activity <i>in vitro</i> with an IC₅₀ of 7.6 μM, as opposed to L-NMMA's IC₅₀ of 41.3 μM. Compound 12 was found to be the most effective inhibitor of alpha-glucosidase enzyme <i>in vitro</i>, with an IC₅₀ value of 42.4 μM (compared to 168 μM for acarbose). Compounds 1-12 were evaluated <i>in vitro</i> for antimicrobial activity using the paper dish method. Compound 11 demonstrated strong antifungal activity against <i>M. gypseum<2024-01-01T00:00:00Z2024 Apr2026-06-02T10:26:19.496Z2025-04-06T00:48:43.06ZS-EPMC110194073862847810.1039/d4ra01865f