{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liu L"],"funding":["National Institutes of Health","NIGMS NIH HHS","National Science Foundation"],"pagination":["113886"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11019558"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["43(3)"],"pubmed_abstract":["The human WDR33 gene encodes three major isoforms. The canonical isoform WDR33v1 (V1) is a well-characterized nuclear mRNA polyadenylation factor, while the other two, WDR33v2 (V2) and WDR33v3 (V3), have not been studied. Here, we report that V2 and V3 are generated by alternative polyadenylation, and neither protein contains all seven WD (tryptophan-aspartic acid) repeats that characterize V1. Surprisingly, V2 and V3 are not polyadenylation factors but localize to the endoplasmic reticulum and interact with stimulator of interferon genes (STING), the immune factor that induces the cellular response to cytosolic double-stranded DNA. V2 suppresses interferon-β induction by preventing STING disulfide oligomerization but promotes autophagy, likely by recruiting WIPI2 isoforms. V3, on the othe"],"journal":["Cell reports"],"pubmed_title":["Non-canonical isoforms of the mRNA polyadenylation factor WDR33 regulate STING-mediated immune responses."],"pmcid":["PMC11019558"],"funding_grant_id":["R35 GM118136"],"pubmed_authors":["Liu L","Manley JL"],"additional_accession":[]},"is_claimable":false,"name":"Non-canonical isoforms of the mRNA polyadenylation factor WDR33 regulate STING-mediated immune responses.","description":"The human WDR33 gene encodes three major isoforms. The canonical isoform WDR33v1 (V1) is a well-characterized nuclear mRNA polyadenylation factor, while the other two, WDR33v2 (V2) and WDR33v3 (V3), have not been studied. Here, we report that V2 and V3 are generated by alternative polyadenylation, and neither protein contains all seven WD (tryptophan-aspartic acid) repeats that characterize V1. Surprisingly, V2 and V3 are not polyadenylation factors but localize to the endoplasmic reticulum and interact with stimulator of interferon genes (STING), the immune factor that induces the cellular response to cytosolic double-stranded DNA. V2 suppresses interferon-β induction by preventing STING disulfide oligomerization but promotes autophagy, likely by recruiting WIPI2 isoforms. V3, on the othe","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2026-05-29T14:14:46.519Z","creation":"2026-04-08T05:00:44.639Z"},"accession":"S-EPMC11019558","cross_references":{"pubmed":["38430516"],"doi":["10.1016/j.celrep.2024.113886"]}}