{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liu D"],"funding":["NIAID NIH HHS","NIMHD NIH HHS","HHS | NIH | National Institute on Minority Health and Health Disparities","NCI NIH HHS","NIGMS NIH HHS"],"pagination":["e0017124"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11019840"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["98(4)"],"pubmed_abstract":["The global impact of emerging viral infections emphasizes the urgent need for effective broad-spectrum antivirals. The cellular organelle, lipid droplet (LD), is utilized by many types of viruses for replication, but its reduction does not affect cell survival. Therefore, LD is a potential target for developing broad-spectrum antivirals. In this study, we found that 2-bromopalmitate (2 BP), a previously defined palmitoylation inhibitor, depletes LD across all studied cell lines and exerts remarkable antiviral effects on different coronaviruses. We comprehensively utilized 2 BP, alongside other palmitoylation inhibitors such as cerulenin and 2-fluoro palmitic acid (2-FPA), as well as the enhancer palmostatin B and evaluated their impact on LD and the replication of human coronaviruses (hCoV"],"journal":["Journal of virology"],"pubmed_title":["2-Bromopalmitate depletes lipid droplets to inhibit viral replication."],"pmcid":["PMC11019840"],"funding_grant_id":["G12 MD007597","SC1 AI112785","SC1 GM135050","SC1 CA200517","G12MD007597"],"pubmed_authors":["Cruz-Cosme R","Tang Q","Leibowitz J","Liu D","Wu Y"],"additional_accession":[]},"is_claimable":false,"name":"2-Bromopalmitate depletes lipid droplets to inhibit viral replication.","description":"The global impact of emerging viral infections emphasizes the urgent need for effective broad-spectrum antivirals. The cellular organelle, lipid droplet (LD), is utilized by many types of viruses for replication, but its reduction does not affect cell survival. Therefore, LD is a potential target for developing broad-spectrum antivirals. In this study, we found that 2-bromopalmitate (2 BP), a previously defined palmitoylation inhibitor, depletes LD across all studied cell lines and exerts remarkable antiviral effects on different coronaviruses. We comprehensively utilized 2 BP, alongside other palmitoylation inhibitors such as cerulenin and 2-fluoro palmitic acid (2-FPA), as well as the enhancer palmostatin B and evaluated their impact on LD and the replication of human coronaviruses (hCoV","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Apr","modification":"2025-04-04T12:58:38.865Z","creation":"2025-04-04T12:58:38.865Z"},"accession":"S-EPMC11019840","cross_references":{"pubmed":["38488361"],"doi":["10.1128/jvi.00171-24"]}}