{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Pan Z"],"funding":["山东省科学技术厅 | Natural Science Foundation of Shandong Province","JST | Natural Science Foundation of Jiangsu Province (Jiangsu Natural Science Foundation)","| Natural Science Foundation of Shandong Province ()","The key program of shandong natural science foundation","MOST | National Key Research and Development Program of China (NKPs)","MOST | National Natural Science Foundation of China (NSFC)","JST | Natural Science Foundation of Jiangsu Province","Guangdong Basic and Applied Basic Research Foundation","MOST | National Key Research and Development Program of China","Postdoctoral Foundation of Qingdao","MOST | National Natural Science Foundation of China"],"pagination":["e0115423"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11019930"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(4)"],"pubmed_abstract":["The chaperone 70 kDa heat shock protein (Hsp70) is important for cells from bacteria to humans to maintain proteostasis, and all eukaryotes and several prokaryotes encode Hsp70 paralogs. Although the mechanisms of Hsp70 function have been clearly illuminated, the function and evolution of Hsp70 paralogs is not well studied. DnaK is a highly conserved bacterial Hsp70 family. Here, we show that <i>dnaK</i> is present in 98.9% of bacterial genomes, and 6.4% of them possess two or more DnaK paralogs. We found that the duplication of <i>dnaK</i> is positively correlated with an increase in proteomic complexity (proteome size, number of domains). We identified the interactomes of the two DnaK paralogs of <i>Myxococcus xanthus</i> DK1622 (MxDnaKs), which revealed that they are mostly nonoverlappi"],"journal":["mSystems"],"pubmed_title":["DnaK duplication and specialization in bacteria correlates with increased proteome complexity."],"pmcid":["PMC11019930"],"funding_grant_id":["32070030, 31670076","2017FY100302","BK20220267","2018YFA0900400, 2018YFA0901704","2022A1515110153","ZR2023QC225","QDBSH20220201044","ZR2023QC136"],"pubmed_authors":["Zhuo L","Pan Z","Chen R-y","Li Y-z","Wan T-y"],"additional_accession":[]},"is_claimable":false,"name":"DnaK duplication and specialization in bacteria correlates with increased proteome complexity.","description":"The chaperone 70 kDa heat shock protein (Hsp70) is important for cells from bacteria to humans to maintain proteostasis, and all eukaryotes and several prokaryotes encode Hsp70 paralogs. Although the mechanisms of Hsp70 function have been clearly illuminated, the function and evolution of Hsp70 paralogs is not well studied. DnaK is a highly conserved bacterial Hsp70 family. Here, we show that <i>dnaK</i> is present in 98.9% of bacterial genomes, and 6.4% of them possess two or more DnaK paralogs. We found that the duplication of <i>dnaK</i> is positively correlated with an increase in proteomic complexity (proteome size, number of domains). We identified the interactomes of the two DnaK paralogs of <i>Myxococcus xanthus</i> DK1622 (MxDnaKs), which revealed that they are mostly nonoverlappi","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Apr","modification":"2026-06-02T19:58:07.702Z","creation":"2024-11-13T12:25:44.528Z"},"accession":"S-EPMC11019930","cross_references":{"pubmed":["38530057"],"doi":["10.1128/msystems.01154-23"]}}