{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Eum DY"],"funding":["Dongnam Institute of Radiological & Medical Sciences","Ministry of Science and ICT, South Korea"],"pagination":["e0296989"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11020960"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["19(4)"],"pubmed_abstract":["Natural anmindenol A isolated from the marine-derived bacteria Streptomyces sp. caused potent inhibition of inducible nitric oxide synthase without any significant cytotoxicity. This compound consists of a structurally unique 3,10-dialkylbenzofulvene skeleton. We previously synthesized and screened the novel derivatives of anmindenol A and identified AM-18002, an anmindenol A derivative, as a promising anticancer agent. The combination of AM-18002 and ionizing radiation (IR) improved anticancer effects, which were exerted by promoting apoptosis and inhibiting the proliferation of FM3A mouse breast cancer cells. AM-18002 increased the production of reactive oxygen species (ROS) and was more effective in inducing DNA damage. AM-18002 treatment was found to inhibit the expansion of myeloid-de"],"journal":["PloS one"],"pubmed_title":["AM-18002, a derivative of natural anmindenol A, enhances radiosensitivity in mouse breast cancer cells."],"pmcid":["PMC11020960"],"funding_grant_id":["50591-2023","RS-2023-00218778"],"pubmed_authors":["Shim JW","Yun H","Choi YJ","Eum DY","Kim J","Heo K","Jeong M","Park SY","Jin Y","Jo J","Lee SR","Park SJ"],"additional_accession":[]},"is_claimable":false,"name":"AM-18002, a derivative of natural anmindenol A, enhances radiosensitivity in mouse breast cancer cells.","description":"Natural anmindenol A isolated from the marine-derived bacteria Streptomyces sp. caused potent inhibition of inducible nitric oxide synthase without any significant cytotoxicity. This compound consists of a structurally unique 3,10-dialkylbenzofulvene skeleton. We previously synthesized and screened the novel derivatives of anmindenol A and identified AM-18002, an anmindenol A derivative, as a promising anticancer agent. The combination of AM-18002 and ionizing radiation (IR) improved anticancer effects, which were exerted by promoting apoptosis and inhibiting the proliferation of FM3A mouse breast cancer cells. AM-18002 increased the production of reactive oxygen species (ROS) and was more effective in inducing DNA damage. AM-18002 treatment was found to inhibit the expansion of myeloid-de","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2026-06-02T06:03:35.969Z","creation":"2026-04-15T03:09:59.893Z"},"accession":"S-EPMC11020960","cross_references":{"pubmed":["38625901"],"doi":["10.1371/journal.pone.0296989"]}}